Single Nucleotide Polymorphisms in Runt-related Transcription Factor 2 and Bone Morphogenetic Protein 2 Impact on Their Maxillary and Mandibular Gene Expression in Different Craniofacial Patterns - A Comparative Study

Autor:	Rafaela Scariot, Bernardo Olsson, MateusJosé da Silva, Camila Lago, RobsonDiego Calixto, LucasAlexandre Ramazzotto, NelsonLuis Barbosa Rebellato, Christian Kirschneck, FranciscoWanderley Garcia Paula-Silva, ErikaCalvano Küchler
Rok vydání:	2021
Předmět:	Surgery Oral Surgery
Zdroj:	Annals of maxillofacial surgery. 11(2)
ISSN:	2231-0746
Popis:	This study aimed to evaluate if single nucleotide polymorphisms (SNPs) in runt-related transcription factor 2 (Lateral cephalometric radiographs were used to classify facial phenotypes based on Steiner's ANB and Ricketts' NBa-PtGn angles. Bone samples from 21 patients collected during orthognathic surgery were used for the gene expression assays. DNA from 129 patients was used for genotyping the SNPs rs59983488 and rs1200425 inA statistically significant difference was observed in the relative BMP2 expression in the mandible between Class I and III participants (In conclusion, BMP2 is expressed differently in the mandible of Class I and Class III participants. Genetic polymorphisms in
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11315c4e5333b173bd549083f7d0bf30 https://pubmed.ncbi.nlm.nih.gov/35265489 Zobrazit plný text záznamu