High-density lipoprotein cholesterol associated with change in coronary plaque lipid burden assessed by near infrared spectroscopy

Autor: Kohei Takata, Peter J. Psaltis, Tracy Nguyen, A. Janssan, Matthew I. Worthley, Stephen J. Nicholls, Daisuke Shishikura, Samuel L. Sidharta, Jordan Andrews, Giuseppe Di Giovanni, Susan Kim, Satoshi Honda
Rok vydání: 2017
Předmět:
Male
medicine.medical_specialty
Pathology
Acute coronary syndrome
Blood lipids
Coronary Artery Disease
030204 cardiovascular system & hematology
Coronary Angiography
Severity of Illness Index
Coronary artery disease
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
High-density lipoprotein
Predictive Value of Tests
Internal medicine
medicine
Humans
030212 general & internal medicine
Acute Coronary Syndrome
skin and connective tissue diseases
Ultrasonography
Interventional
Aged
Chi-Square Distribution
Spectroscopy
Near-Infrared
Triglyceride
Cholesterol
business.industry
Cholesterol
HDL
Middle Aged
medicine.disease
Coronary Vessels
Plaque
Atherosclerotic
chemistry
Predictive value of tests
Multivariate Analysis
Linear Models
Cardiology
Female
lipids (amino acids
peptides
and proteins)
sense organs
Cardiology and Cardiovascular Medicine
business
Biomarkers
Lipoprotein
Zdroj: Atherosclerosis. 265:110-116
ISSN: 0021-9150
Popis: Background and aims Little is known about the relation between serum lipid parameters and serial change in plaque composition using in vivo coronary imaging. The aim of this study was to examine the association between serum lipids and change in coronary plaque lipid burden assessed by near-infrared spectroscopy (NIRS). Methods We performed serial NIRS-intravascular ultrasound studies in 49 patients who underwent coronary angiography for an acute coronary syndrome (ACS) or stable ischemic symptoms. Univariable and multivariable linear regression analyses were applied to evaluate the relationship between serum lipid parameters and change in lipid core burden index at the 4-mm maximal segment (max LCBI 4mm ). Results Mean patient age was 61 ± 9 y, 29% were women, 35% had an ACS clinical presentation, 78% received statin therapy at baseline, and median low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), total cholesterol and triglyceride levels were 101, 43, 174 and 133 mg/dL, respectively. During a median follow-up period of 13 months, max LCBI 4mm significantly decreased from 277 to 194 ( p = 0.001). On univariable analysis, the percent change in HDL-C negatively associated with the change in max LCBI 4mm (β = −3.19, p = 0.004). There were no significant associations between the other lipid parameters and change in max LCBI 4mm . On multivariable analysis, percent change in HDL-C remained significantly associated with the change in max LCBI 4mm ( p = 0.002). Conclusions Change in HDL-C, but not other lipids parameters, associated with changes in coronary plaque lipid burden assessed by NIRS. These findings highlight the potential therapeutic importance of high-density lipoprotein on serial change in plaque composition.
Databáze: OpenAIRE
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