High-density lipoprotein cholesterol associated with change in coronary plaque lipid burden assessed by near infrared spectroscopy
Autor: | Kohei Takata, Peter J. Psaltis, Tracy Nguyen, A. Janssan, Matthew I. Worthley, Stephen J. Nicholls, Daisuke Shishikura, Samuel L. Sidharta, Jordan Andrews, Giuseppe Di Giovanni, Susan Kim, Satoshi Honda |
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Rok vydání: | 2017 |
Předmět: |
Male
medicine.medical_specialty Pathology Acute coronary syndrome Blood lipids Coronary Artery Disease 030204 cardiovascular system & hematology Coronary Angiography Severity of Illness Index Coronary artery disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Predictive Value of Tests Internal medicine medicine Humans 030212 general & internal medicine Acute Coronary Syndrome skin and connective tissue diseases Ultrasonography Interventional Aged Chi-Square Distribution Spectroscopy Near-Infrared Triglyceride Cholesterol business.industry Cholesterol HDL Middle Aged medicine.disease Coronary Vessels Plaque Atherosclerotic chemistry Predictive value of tests Multivariate Analysis Linear Models Cardiology Female lipids (amino acids peptides and proteins) sense organs Cardiology and Cardiovascular Medicine business Biomarkers Lipoprotein |
Zdroj: | Atherosclerosis. 265:110-116 |
ISSN: | 0021-9150 |
Popis: | Background and aims Little is known about the relation between serum lipid parameters and serial change in plaque composition using in vivo coronary imaging. The aim of this study was to examine the association between serum lipids and change in coronary plaque lipid burden assessed by near-infrared spectroscopy (NIRS). Methods We performed serial NIRS-intravascular ultrasound studies in 49 patients who underwent coronary angiography for an acute coronary syndrome (ACS) or stable ischemic symptoms. Univariable and multivariable linear regression analyses were applied to evaluate the relationship between serum lipid parameters and change in lipid core burden index at the 4-mm maximal segment (max LCBI 4mm ). Results Mean patient age was 61 ± 9 y, 29% were women, 35% had an ACS clinical presentation, 78% received statin therapy at baseline, and median low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), total cholesterol and triglyceride levels were 101, 43, 174 and 133 mg/dL, respectively. During a median follow-up period of 13 months, max LCBI 4mm significantly decreased from 277 to 194 ( p = 0.001). On univariable analysis, the percent change in HDL-C negatively associated with the change in max LCBI 4mm (β = −3.19, p = 0.004). There were no significant associations between the other lipid parameters and change in max LCBI 4mm . On multivariable analysis, percent change in HDL-C remained significantly associated with the change in max LCBI 4mm ( p = 0.002). Conclusions Change in HDL-C, but not other lipids parameters, associated with changes in coronary plaque lipid burden assessed by NIRS. These findings highlight the potential therapeutic importance of high-density lipoprotein on serial change in plaque composition. |
Databáze: | OpenAIRE |
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