EOLIA trial: the future of extracorporeal membrane oxygenation in acute respiratory distress syndrome therapy?
| Autor: | Zhou Meng, Ellen T Marciniak, Muhammad Sameed |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
lcsh:RC705-779 medicine.medical_specialty ARDS Journal Club business.industry medicine.medical_treatment Acute respiratory distress lcsh:Diseases of the respiratory system Expert Opinion medicine.disease 03 medical and health sciences surgical procedures operative 0302 clinical medicine Text mining 030228 respiratory system medicine Extracorporeal membrane oxygenation 030212 general & internal medicine Intensive care medicine business |
| Zdroj: | Breathe, Vol 15, Iss 3, Pp 244-246 (2019) Breathe |
| ISSN: | 2073-4735 1810-6838 |
| Popis: | This was a prospective, multi-centre randomised controlled trial that involved centres in 16 countries. The trial was designed as a group sequential analysis with data analysed after randomisation of every 60 participants; stopping rules were predefined using the two triangle method. The trial could be stopped due to safety (due to excessive mortality in the ECMO arm), efficacy or futility (if unlikely to reach a definitive result). The trial was designed to have a power of 80% and alpha level of 5% to detect an absolute risk reduction of 20%. It was hypothesised that the mortality would be 60% in the conventional arm and 40% in the ECMO arm. Mortality at 60 days was the primary outcome measured. In the EOLIA trial, early use of ECMO did not significantly improve mortality at 60 days in patients with severe ARDS, but when used as a rescue modality ECMO might help improve survival http://bit.ly/2XOjwSE |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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