Cov19VaxKB: A web-based integrative COVID-19 vaccine knowledge base

Autor: Philip C. Huang, Rohit Goru, Anthony Huffman, Asiyah Yu Lin, Michael F. Cooke, Yongqun He
Rok vydání: 2022
Předmět:
NCBI
National Center for Biotechnology Information
adverse event
VAERS
Vaccine Adverse Event Reporting System
Article
WHO
World Health Organization
PRR
Proportional Reporting Ratio
VIOLIN
Vaccine Investigation and Online Information Network
vaccine
VO
Vaccine Ontology
VAERS
ontology
SARS-CoV
Severe Acute Respiratory Syndrome Coronavirus
FDA
Food and Drug Administration
database
CDC
Centers for Disease Control and Prevention
COVID-19
Coronavirus disease 2019
General Veterinary
General Immunology and Microbiology
SARS-CoV-2
Public Health
Environmental and Occupational Health
COVID-19
bioinformatics
RC581-607
Cov19VaxKB
SARS-CoV-2
Severe Acute Respiratory Syndrome Coronavirus 2
Infectious Diseases
OWL
Web Ontology Language
Molecular Medicine
knowledge base
Immunologic diseases. Allergy
COVID-19 vaccine
AE
adverse event
MERS-CoV
Middle Eastern Respiratory Syndrome
PMID
PubMed identification number
Zdroj: Vaccine: X
Vaccine: X, Vol 10, Iss, Pp 100139-(2022)
ISSN: 2590-1362
DOI: 10.1016/j.jvacx.2021.100139
Popis: The development of SARS-CoV-2 vaccines during the COVID-19 pandemic has prompted the emergence of COVID-19 vaccine data. Timely access to COVID-19 vaccine information is crucial to researchers and public. To support more comprehensive annotation, integration, and analysis of COVID-19 vaccine information, we have developed Cov19VaxKB, a knowledge-focused COVID-19 vaccine database (http://www.violinet.org/cov19vaxkb/). Cov19VaxKB features comprehensive lists of COVID-19 vaccines, vaccine formulations, clinical trials, publications, news articles, and vaccine adverse event case reports. A web-based query interface enables comparison of product information and host responses among various vaccines. The knowledge base also includes a vaccine design tool for predicting vaccine targets and a statistical analysis tool that identifies enriched adverse events for FDA-authorized COVID-19 vaccines based on VAERS case report data. To support data exchange, Cov19VaxKB is synchronized with Vaccine Ontology and the Vaccine Investigation and Online Information Network (VIOLIN) database. The data integration and analytical features of Cov19VaxKB can facilitate vaccine research and development while also serving as a useful reference for the public.
Databáze: OpenAIRE
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