Respiratory mechanics in normal hamsters
| Autor: | D. E. Leith, K. W. Koo, G. L. Snider, C. B. Sherter |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Pentobarbital
Functional Residual Capacity Physiology Respiratory physiology Pulmonary compliance Functional residual capacity Physiology (medical) Cricetinae Pressure Medicine Plethysmograph Animals Lung volumes Lung Lung Compliance business.industry Respiration Body Weight Organ Size respiratory system respiratory tract diseases medicine.anatomical_structure Anesthesia business Nuclear medicine Lung Volume Measurements medicine.drug Transpulmonary pressure |
| Zdroj: | Journal of applied physiology. 40(6) |
| ISSN: | 0021-8987 |
| Popis: | Lung volumes and quasi-static deflation volume-pressure relationships were measured in male golden hamsters anesthetized with pentobarbital. Volume was measured with a pressure plethysmograph, and pleural pressure was estimated by the use of a water-filled esophageal catheter. Mean body weight +/- SE was 122.3 +/-3.0 g, mean lung weight was 0.74 +/- 0.2 g or about 0.6% of body weight. Mean lung volume at 25 cmH2O transpulmonary pressure (TLC25) was 7.2 +/- 0.14 ml, 9.78 +/- 0.17 ml/g lung weight or 5.92 +/- 0.06 ml/100 g body weight. Mean functional residual capacity was 2.4 +/- 0.06 ml or 33.3% of TLC25. Mean vital capacity was 5.2 +/- 0.13 ml. Mean quasi-static compliance of lung was 0.63 +/- 0.03 ml/cmH2O. Chord compliance of chest wall between lung volumes of 1 and 4 ml above RV was 3.39 +/- 0.53 ml/cmH2O. At FRC, the chest wall recoiled inward, so that pleural pressure was positive (1.4 +/- 0.13 cmH2O) and the lung was resisting further collapse. The slope of the lung′s deflation volume-pressure curve changed at FRC, ERV was small (0.36 +/- 0.03 ml), and RV was determined by complete airway closure. Thus the mechanisms determining FRC are unusual and include an influence of airway closure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|