Induction chemotherapy with cisplatin, fluorouracil, and high-dose leucovorin for squamous cell carcinoma of the head and neck: long-term results
| Autor: | Rosemary Costello, L. Thornhill, J. Lucarini, M Lackey, Arnon I. Dreyfuss, Mark Poulin, John W. Clark, D Lucarini, A. D. Colevas, Edward S. Peters, C. M. Norris, Roy B. Tishler, Janet Andersen, Paul M. Busse, Renee M. Rossi, Marshall R. Posner |
|---|---|
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Leucovorin Gastroenterology Drug Administration Schedule Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Stage (cooking) Aged Neoplasm Staging Cisplatin Chemotherapy business.industry Remission Induction Induction chemotherapy Middle Aged medicine.disease Primary tumor Survival Analysis Surgery Radiation therapy Treatment Outcome Oncology Epidermoid carcinoma Fluorouracil Head and Neck Neoplasms Carcinoma Squamous Cell Female business medicine.drug |
| Zdroj: | Europe PubMed Central |
| Popis: | PURPOSE A phase II trial of cisplatin, fluorouracil, and leucovorin (PFL) induction chemotherapy in patients with locally advanced squamous cell carcinomas of the head and neck region (HNCA). PATIENTS AND METHODS One hundred two patients (stage III/IV, previously untreated) were treated with induction PFL. Patients with resectable primary tumor site lesions and clinical complete response (CR) were offered radiotherapy (RT) without surgery to the primary tumor site. Response, toxicity, local-regional therapy, survival, and preservation of the primary tumor site were assessed. RESULTS Among 279 courses, the overall response rate was 81%. Nineteen (19%) failed to respond, including three who died during therapy. Sixty-seven (69%) of 97 with assessable primary lesions had a clinical CR at the primary tumor site. Pathologic CR was recorded in 46 of 55 (84%) clinical CR patients who had biopsies performed on the primary tumor site. Toxicities resulted in unexpected hospitalizations in 19% of cases. After definitive local-regional therapy, 84 (82%) were disease-free including 71 (69%) with preserved primary tumor site anatomy. With a median follow-up time of 63 months, the cause-specific, overall (OS), and failure-free survival (FFS) rates at 5 years are 58%, 52%, and 51%. Local failure occurred in 29 of 102 (29%) and the local control rate at 5 years was 68%. CONCLUSION PFL has significant activity with acceptable toxicity in patients with advanced disease who have a good performance status. Preservation of the primary tumor site could be achieved without apparent loss of local control or survival. Management of neck disease by surgery or RT must be individualized and separate from management of primary tumor. Survival compares favorably with similar trials of induction chemotherapy or chemoradiotherapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|