| Autor: |
Nicholas L. Wood, Douglas N. VanDerwerken, Dorry L. Segev, Sommer E. Gentry |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation SocietyREFERENCES. |
| ISSN: |
1527-6473 |
| Popis: |
Recent changes to liver allocation replaced donor service areas with circles as the geographic unit of allocation. Circle-based allocation might increase the number of transplantation centers and candidates required to place a liver, thereby increasing the logistical burden of making and responding to offers on organ procurement organizations and transplantation centers. Circle-based allocation might also increase distribution time and cold ischemia time (CIT), particularly in densely populated areas of the country, thereby decreasing allocation efficiency. Using Scientific Registry of Transplant Recipient data from 2019 to 2021, we evaluated the number of transplantation centers and candidates required to place livers in the precircles and postcircles eras, nationally and by donor region. Compared with the precircles era, livers were offered to more candidates (5 vs. 9; p 0.001) and centers (3 vs. 5; p 0.001) before being accepted; more centers were involved in the match run by offer number 50 (9 vs. 14; p 0.001); CIT increased by 0.2 h (5.9 h vs. 6.1 h; p 0.001); and distribution time increased by 2.0 h (30.6 h vs. 32.6 h; p 0.001). Increased burden varied geographically by donor region; livers recovered in Region 9 were offered to many more candidates (4 vs. 12; p 0.001) and centers (3 vs. 8; p 0.001) before being accepted, resulting in the largest increase in CIT (5.4 h vs. 6.0 h; p 0.001). Circle-based allocation is associated with increased logistical burdens that are geographically heterogeneous. Continuous distribution systems will have to be carefully designed to avoid exacerbating this problem. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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