Lymphotactin: a cytokine that represents a new class of chemokine
| Autor: | Sarah Kleyensteuber, Albert Zlotnik, Kevin W. Moore, David A. Largaespada, Thomas J. Schall, Gregory S. Kelner, J. Fernando Bazan, Nancy A. Jenkins, Jacqueline L. Kennedy, Neal G. Copeland, Kevin B. Bacon |
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| Rok vydání: | 1994 |
| Předmět: |
XCR1
Chemokine medicine.medical_treatment Sialoglycoproteins Molecular Sequence Data Biology Cell Line Mice T-Lymphocyte Subsets medicine CXCL10 Animals Humans Amino Acid Sequence Chemokine CCL4 Lymphokines Mice Inbred BALB C Multidisciplinary Base Sequence Monokines Macrophage Inflammatory Proteins Hematopoietic Stem Cells Molecular biology Recombinant Proteins Chemokines C Chemotaxis Leukocyte Cytokine Immunology biology.protein XCL2 Cytokines Calcium CCL23 Sequence Alignment CD8 XCL1 Signal Transduction |
| Zdroj: | Science (New York, N.Y.). 266(5189) |
| ISSN: | 0036-8075 |
| Popis: | In this study, the cytokine-producing profile of progenitor T cells (pro-T cells) was determined. During screening of a complementary DNA library generated from activated mouse pro-T cells, a cytokine designated lymphotactin was discovered. Lymphotactin is similar to members of both the Cys-Cys and Cys-X-Cys chemokine families but lacks two of the four cysteine residues that are characteristic of the chemokines. Lymphotactin is also expressed in activated CD8+ T cells and CD4-CD8- T cell receptor alpha beta + thymocytes. It has chemotactic activity for lymphocytes but not for monocytes or neutrophils. The gene encoding lymphotactin maps to chromosome one. Taken together, these observations suggest that lymphotactin represents a novel addition to the chemokine superfamily. |
| Databáze: | OpenAIRE |
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