Accelerated chemotherapy with mitoxantrone plus g-csf in heavily pretreated patients with metastatic breast-cancer
| Autor: | R Sarcina, C. Tatulli, M Delena, Lorusso, F Berardi |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Mitoxantrone Chemotherapy Leukopenia business.industry medicine.medical_treatment Cancer General Medicine medicine.disease Gastroenterology Metastatic breast cancer Granulocyte colony-stimulating factor Breast cancer Internal medicine Concomitant medicine medicine.symptom business medicine.drug |
| Zdroj: | Oncology reports. 1(3) |
| ISSN: | 1021-335X |
| Popis: | Twenty-two women with metastatic breast cancer, previously submitted to one or more lines of chemotherapy, were treated with mitoxantrone as single agent delivered at full dosage (14 mg/m(2)) every other week (accelerated chemotherapy). This dose was possible with concomitant subcutaneous administration of granulocyte colony stimulating factor (G-CSF) on days 5 to 12 of each 14 day cycle. Although grade III-IV leukopenia, anemia and thrombocytopenia were observed in 50%, 13%, and 27% of cases, respectively, a complete recovery of neutrophils, due to G-CSF administration, permitted on time cycle delivery in the majority of cases. Partial response was observed in 6/22 patients (27%). In conclusion, accelerated chemotherapy with mithoxantrone plus G-CSF is both feasible and effective for patients with previously treated breast cancer. |
| Databáze: | OpenAIRE |
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