Regio- and Enantioselective Allylic Alkylation of Terminal Alkynes by Synergistic Rh/Cu Catalysis
| Autor: | Samir Ghorai, Wen-Yu Huang, Changkun Li, Bing Li, Chun-Hua Lu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Allylic rearrangement
Chemistry Enantioselective synthesis Sonogashira coupling General Chemistry Bond formation 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry Catalysis Reductive elimination 0104 chemical sciences Tsuji–Trost reaction Colloid and Surface Chemistry Stoichiometry |
| Zdroj: | Journal of the American Chemical Society. 142(36) |
| ISSN: | 1520-5126 |
| Popis: | A highly branch- and enantioselective 1,4-enynes synthesis from readily available terminal alkynes and racemic allylic carbonates by Sonogashira type synergistic Rh and Cu catalysis under neutral conditions has been developed. Aliphatic and aromatic terminal alkynes with various functional groups could be used directly. An inner-sphere reductive elimination C(sp)-C(sp3) bond formation mechanism is supported by the stoichiometric reaction. |
| Databáze: | OpenAIRE |
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