t-BuOK-mediated hydrophosphination of functionalized alkenes: a novel synthesis of chiral P,N- and P,P-ligands

Autor:	Tanasri Bunlaksananusorn, Paul Knochel
Rok vydání:	2004
Předmět:	Chemistry Stereochemistry Organic Chemistry Hydrophosphination General Medicine Medicinal chemistry
Zdroj:	The Journal of organic chemistry. 69(14)
ISSN:	0022-3263
Popis:	A novel synthesis of effective chiral P,N- and P,P-ligands has been developed by using a t-BuOK-mediated hydrophosphination of chiral alkenylpyridines and alkenylphosphine oxides. Ir complexes of chiral P,N-ligands 1 and 3 gave high enantioselectivities for the hydrogenation of (Z)-alpha-(acetamido)cinnamate 25 and (E)-1,2-diphenylpropene leading to the hydrogenated products with up to 97% ee.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11219a0040d248c4ebe07c58f5f0a81b https://pubmed.ncbi.nlm.nih.gov/15230580 Zobrazit plný text záznamu