Stimulant effect of human gamma globulin on smooth muscle preparations
| Autor: | Morley C. Sutter, Silvia D. Chang, Zuheir Abrahams |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Contraction (grammar) Guinea Pigs Aorta Thoracic Biology In Vitro Techniques Muscle Smooth Vascular Guinea pig Contractility Internal medicine medicine.artery medicine Animals Humans Respiratory system Rats Wistar Pharmacology Aorta Portal Vein Gamma globulin Muscle Smooth Rats Trachea medicine.anatomical_structure Endocrinology Circulatory system gamma-Globulins Blood vessel Muscle Contraction |
| Zdroj: | European journal of pharmacology. 238(2-3) |
| ISSN: | 0014-2999 |
| Popis: | The effects of human gamma globulin on the contractile activity of spontaneously active rat mesenteric portal vein and guinea-pig taenia caeni and quiescent rat aorta and guinea-pig trachea muscles were studied in vitro. Human gamma globulin significantly increased the contractile activity of the spontaneously active muscles with respect to both amplitude and frequency of contraction whereas it had no significant effect on the contractile activity of guiescent muscle preparations. These findings suggest that immunoglobulins directly modulate smooth muscle including vasculature by modifying the membrane electrical activity associated with the generation of spontaneous activity. |
| Databáze: | OpenAIRE |
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