| Autor: |
Mitch Dowsett, Lesley-Ann Martin, Irene Kuter, Jill Walker, Robert Wellings, Justin Lindemann, Alan Mackay, Roger A'hern, Qiong Gao, Elizabeth Anderson, Ricardo Ribas, Zara Ghazoui, Helen Anderson, Anita K. Dunbier, Neill Patani |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1078-0432.22451022 |
| Popis: |
PDF file - 556KB, Supplementary Figure 1a: Overview of pre-surgical studies: Fulvestrant (NEWEST), detailing study design (i) and samples (ii). S1b: Anastrozole (FAIMoS), detailing study design (i) and samples (ii). S1c: Summary of patient demographics and tumour characteristics for NEWEST and FAIMoS; Supplementary Figure 2ai: Spearman correlations between fulvestrant (F) and E-deprivation (ED) related and specific genes, selected proliferation-associated and E-regulated index genes in pre-treatment samples from NEWEST (n=22). Direct correlations are indicated in red and inverse correlations in green, with their strength reflected by colour intensity. S2aii: Spearman correlations between fulvestrant (F) and E-deprivation (ED) related and specific genes, selected proliferation-associated and E-regulated index genes in pre-treatment samples from FAIMoS (n=81). Direct correlations are indicated in red and inverse correlations in green, with their strength reflected by colour intensity. Supplementary Figure 2b: Summary of Spearman correlations between up-regulated (n=13) and down-regulated (n=28) genes which were fulvestrant-related (n=41), AURKA and ESR1, in pre-treatment in samples from (i) NEWEST and (ii) FAIMoS. Supplementary Figure 3a/b: mpact of ESR1 knockdown with an siRNA SMARTpool and four constituent oligonucleotides (a), on the mRNA expression of genes differentially down-regulated by fulvestrant (b). S3c: Impact of ESR1 knockdown with an siRNA SMARTpool and four constituent oligonucleotides (a), on the mRNA expression of genes differentially up-regulated by fulvestrant (c). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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