An evaluation of a unique new antipsychotic agent, sulpiride: effects on serum prolactin and growth hormone levels
| Autor: | Gallant Dm, Mielke Dh, Kessler C |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Adult
Male Dyskinesia Drug-Induced medicine.medical_specialty medicine.medical_treatment Hypothalamus Tardive dyskinesia Antipsychotic Agent Internal medicine Humans Medicine Antipsychotic Clinical Trials as Topic Dose-Response Relationship Drug business.industry Dopaminergic medicine.disease Prolactin Psychiatry and Mental health Endocrinology Schizophrenia Growth Hormone Drug Evaluation Female Sulpiride business Antipsychotic Agents medicine.drug |
| Zdroj: | American Journal of Psychiatry. 134:1371-1375 |
| ISSN: | 1535-7228 0002-953X |
| DOI: | 10.1176/ajp.134.12.1371 |
| Popis: | Sulpiride is a new and chemically different neuroleptic. In a study of 16 severely ill schizophrenic patients, this compound displayed definite evidence of antipsychotic activity while producing few adverse reactions. The relative absence of extrapyramidal side effects may indicate that sulpride has a low potential for producing tardive dyskinesia. Two patients who did not develop significant increases in prolactin levels did show a definite therapeutic response to sulpiride. Thus it appears that central dopaminergic blockade in the hypothalamic area is not a prerequisite for antipsychotic activity. |
| Databáze: | OpenAIRE |
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