Protective effects of melatonin on lung damage associated with one-lung ventilation: An experimental study
| Autor: | Cigdem Cengelli, Muammer Cumhur Sivrikoz, Erhan Durceylan, Kevser Erol, Ebubekir Aksu, Emine Kasapoglu, Evrim Yilmaz, Hacer Boztepe |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Superoxide dismutase Melatonin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Lung biology business.industry Malondialdehyde One lung ventilation Endocrinology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Breathing biology.protein Original Article Surgery Histopathology Tumor necrosis factor alpha Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Turk gogus kalp damar cerrahisi dergisi. 28(1) |
| ISSN: | 1301-5680 |
| Popis: | BACKGROUND: This study aims to investigate the protective effect of melatonin on lung damage induced by one-lung ventilation in a rat model. METHODS: A total of 20 healthy, Sprague-Dawley male rats were randomized into two equal groups as control (n=10) and melatonin groups (n=10). The control group underwent 60 min of one-lung ventilation, followed by 30 min of two-lung ventilation. In the melatonin group, the rats were administered 10 mg/kg melatonin intraperitoneally 10 min before the start of the experiment. At the end of both ventilation periods, tissue samples were obtained from the lungs of the control and melatonin groups for biochemical analysis and histopathological examinations. Tissue superoxide dismutase, malondialdehyde, and tumor necrosis factor-alpha levels were measured. Lung tissue samples were examined based on the presence and amount of alveolar congestion, intra-alveolar bleeding, and leukocyte and lymphocyte infiltration. RESULTS: At the end of the study, lung tissue malondialdehyde (3.8±0.9 vs. 1.8±0.8 μM; p |
| Databáze: | OpenAIRE |
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