Wrinkle reduction using a Sasang constitutional medicine-based topical herbal cream in So-eum subjects: A split-face randomized double-blind placebo-controlled study
Autor: | Young Kyoung Seo, Kon-Young Ji, Jong Yeol Kim, Jiho Nam, A-Rang Im, Seongwon Cha, Jiwon Yoon, Sungwook Chae |
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Rok vydání: | 2022 |
Předmět: |
Sasang constitutional medicine
So-eum type 0211 other engineering and technologies Placebo-controlled study Human skin 02 engineering and technology Anti-wrinkle Placebo Skin Aging 03 medical and health sciences 0302 clinical medicine Cassia 021105 building & construction Medicine Curcuma Miscellaneous systems and treatments Wrinkle biology Traditional medicine business.industry RZ409.7-999 food and beverages biology.organism_classification 030205 complementary & alternative medicine Complementary and alternative medicine Original Article Zingiber officinale Herbal medicine medicine.symptom business |
Zdroj: | Integrative Medicine Research Integrative Medicine Research, Vol 11, Iss 1, Pp 100752-(2022) |
ISSN: | 2213-4220 |
Popis: | Background Skin aging is caused by exogenous and endogenous factors and is commonly manifested as wrinkling, sagging, and looseness of the skin. The herbal extract including Zingiber officinale Roscoe, Atractylodes chinensis (Bunge) Kodiz, Curcuma longa L., and Cinnamomum cassia (L.) J.Presl (ZACC extract), is widely used for So-eum (SE) Sasang constitutional type individuals. This study aimed to examine the protective effects of the ZACC extract against skin aging in 21 SE type subjects. Methods The safety and clinical efficacy of herbal cream were evaluated after application on human skin in a split-face randomized, double-blind, placebo-controlled study. The Sasang Constitution Analysis Tool (SCAT) was used to select 21 SE type subjects, who applied herbal cream and placebo cream for 12 weeks. Visual assessment, wrinkle parameters, questionnaires, and skin safety were evaluated. Results The visual assessment score was decreased by using of the herbal cream, but there were no significant differences between groups. Among the wrinkle parameters, R1 (skin roughness) and R4 (smoothness depth) values were significantly improved after the application of the herbal cream compared to those observed after application of the placebo cream for 12 weeks. No significant differences were observed in evaluation of the product efficacy and usability by questionnaires. There were no adverse dermatologic reactions in the SE type subjects during the evaluation period. Conclusion The ZACC herbal cream may be used to prevent or slow skin aging, including wrinkle formation, in SE type individuals. |
Databáze: | OpenAIRE |
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