Phytochemistry and antifungal properties of the newly discovered tree Pleodendron costaricense
Autor: | Virginie Treyvaud Amiguet, Ronaldo Nuñez, Pablo Sanchez-Vindas, John T. Arnason, Chieu Anh Ta, Myron L. Smith, Philippe Petit, Luis Poveda Alvarez, T. Durst |
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Rok vydání: | 2006 |
Předmět: |
Azoles
Costa Rica Phytochemistry Antifungal Agents Stereochemistry Polygodial Allyl compound Pharmaceutical Science Dioxoles Biology Sesquiterpene Alternaria alternata Analytical Chemistry Trees chemistry.chemical_compound Drug Discovery Candida albicans Exophiala Cytochrome P-450 Enzyme Inhibitors Pharmacology Traditional medicine Molecular Structure Organic Chemistry Alternaria Drug Resistance Microbial biology.organism_classification Terpenoid Allyl Compounds Plant Leaves Complementary and alternative medicine chemistry Phytochemical Plant Bark Molecular Medicine Sesquiterpenes |
Zdroj: | Journal of natural products. 69(7) |
ISSN: | 0163-3864 |
Popis: | Gas chromatography analysis of the essential oils of leaves and bark collected from the newly discovered tree Pleodendron costaricense identified alpha-pinene, beta-pinene, beta-myrcene, beta-thujene, and beta-caryophyllene as their major constituents. Phytochemical analysis of P. costaricense parts led to the isolation and identification of delta-tocotrienol, beta-sitosterol, four known drimane-type sesquiterpenes, cinnamodial (1), cinnamosmolide (2), polygodial (3), and mukaadial (4), and two new compounds, a drimane-type sesquiterpene, parritadial (5), and an eremophilane-type sesquiterpene, pleodendione (6). Antifungal assays with the two major compounds, 1 and 2, were carried out, and results showed a high activity of 1 against Alternaria alternata (MIC = 3.9 microg/mL), Candida albicans azole-resistant strain D10, and Wangiella dermatitides (MICs = 15.6 microg/mL). Compound 2 showed less potent antifungal activities than 1 but was more effective against Candida albicans azole-resistant strain CN1A (MIC = 23.4 microg/mL) and Pseudallescheria boydii (MIC = 78.1 microg/mL). A combination of the dialdehyde sesquiterpenes with dillapiol showed a synergistic antifungal effect with 1 and an additive effect with 4 and 5. |
Databáze: | OpenAIRE |
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