BRAF mutations, microsatellite instability status and cyclin D1 expression predict metastatic colorectal patients’ outcome
| Autor: | E Bairaktari, Dionysis Papadatos-Pastos, Z. Saridaki, V. Georgoulias, John Souglakos, H Arvanity, D. Mavroudis, Maria Tzardi, E. Stathopoulos |
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| Rok vydání: | 2010 |
| Předmět: |
Proto-Oncogene Proteins B-raf
Adult Male Oncology Cancer Research medicine.medical_specialty Colorectal cancer Cyclin D BRAF mutations Disease-Free Survival Metastasis Cyclin D1/*metabolism Cyclin D1 MSI status Internal medicine Colorectal Neoplasms/drug therapy/*genetics/mortality/pathology medicine Humans cyclin D1 expression Microsatellite Instability Neoplasm Metastasis Molecular Diagnostics neoplasms Aged Aged 80 and over biology Cancer Microsatellite instability Mutation Middle Aged Cell cycle Prognosis medicine.disease digestive system diseases biology.protein Cancer research Female Proto-Oncogene Proteins B-raf/*genetics Colorectal Neoplasms metastatic CRC V600E |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6605694 |
| Popis: | BACKGROUND: The significance of BRAF mutations, microsatelite instability (MSI) status and cyclin D1 expression in patients with metastatic colorectal cancer (mCRC) was evaluated. METHODS: Primary tumours from 144 patients treated for mCRC were assessed for BRAF (V600E) mutation, MSI status and cyclin D1. The data were correlated with progression-free survival (PFS) and overall survival (OS). RESULTS: BRAF mutations were detected in 10 (out of 22, 45%) patients with MSI-H tumours compared with 2 (out of 122, 1.6%) in those with microsatellite stable tumours (P |
| Databáze: | OpenAIRE |
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