An Integrated Multilevel Analysis Profiling Biosafety and Toxicity Induced by Indium- and Cadmium-Based Quantum Dots in Vivo
| Autor: | Antonella Bauduin, Mariateresa Allocca, María Moros, Claudia Tortiglione, Beata Miedziak, Luca De Trizio, Alfredo Ambrosone, Peter Reiss, Angela Tino, Lucia Mattera |
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| Přispěvatelé: | Istituto di Scienze Applicate e Sistemi Intelligenti 'Eduardo Caianiello' (ISASI), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Synthèse, Structure et Propriétés de Matériaux Fonctionnels (STEP), SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé (SYMMES), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Département Interfaces pour l'énergie, la Santé et l'Environnement (DIESE), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Istituto Italiano di Tecnologia (IIT), University of Salerno (UNISA), ANR-16-CE09-0015,NEUTRINOS,Suivi des interactions biologiques par détection optique ultrasensible à base de nanoparticules(2016), ANR-18-CE09-0039,FLUO,Synthèse en flux continu de quantum dots à base d'InP(2018), Agence Nationale de la Recherche (France), European Commission, Trizio, Luca de [0000-0002-1514-6358], Tino, Angela [0000-0002-9673-1064], Reiss, Peter [0000-0002-9563-238X], Trizio, Luca de, Tino, Angela, Reiss, Peter |
| Rok vydání: | 2019 |
| Předmět: |
Photoluminescence
Materials science Biocompatibility Nanotechnology 010501 environmental sciences 01 natural sciences Indium chemistry.chemical_compound In vivo Quantum Dots Cadmium Compounds Environmental Chemistry [CHIM]Chemical Sciences QD model organism 0105 earth and related environmental sciences technology industry and agriculture General Chemistry Containment of Biohazards equipment and supplies Cadmium telluride photovoltaics 3. Good health chemistry Quantum dot Zinc Compounds Indium phosphide Multilevel Analysis Nanomedicine Nanorod Tellurium Cadmium |
| Zdroj: | Environmental Science and Technology Environmental Science and Technology, 2019, 53 (7), pp.3938-3947. ⟨10.1021/acs.est.9b00373⟩ Environmental science & technology 53 (2019): 3938–3947. doi:10.1021/acs.est.9b00373 info:cnr-pdr/source/autori:Allocca, Mariateresa; Mattera, Lucia; Bauduin, Antonella; Miedziak, Beata; Moros, Maria; De Trizio, Luca; Tino, Angela; Reiss, Peter; Ambrosone, Alfredo; Tortiglione, Claudia/titolo:An Integrated Multilevel Analysis Profiling Biosafety and Toxicity Induced by Indium-and Cadmium-Based Quantum Dots in Vivo/doi:10.1021%2Facs.est.9b00373/rivista:Environmental science & technology/anno:2019/pagina_da:3938/pagina_a:3947/intervallo_pagine:3938–3947/volume:53 Digital.CSIC. Repositorio Institucional del CSIC instname Zaguán. Repositorio Digital de la Universidad de Zaragoza |
| ISSN: | 1520-5851 0013-936X |
| Popis: | Indium phosphide quantum dots (QDs) have emerged as a new class of fluorescent nanocrystals for manifold applications, from biophotonics to nanomedicine. Recent efforts in improving the photoluminescence quantum yield, the chemical stability and the biocompatibility turned them into a valid alternative to well established Cd-based nanocrystals. In vitro studies provided first evidence for the lower toxicity of In-based QDs. Nonetheless, an urgent need exists for further assessment of the potential toxic effects in vivo. Here we use the freshwater polyp Hydra vulgaris, a well-established model previously adopted to assess the toxicity of CdSe/CdS nanorods and CdTe QDs. A systematic multilevel analysis was carried out in vivo, ex vivo, and in vitro comparing toxicity end points of CdSe- and InP-based QDs, passivated by ZnSe/ZnS shells and surface functionalized with penicillamine. Final results demonstrate that both the chemical composition of the QD core (InP vs CdSe) and the shell play a crucial role for final outcomes. Remarkably, in absence of in vivo alterations, cell and molecular alterations revealed hidden toxicity aspects, highlighting the biosafety of InP-based nanocrystals and outlining the importance of integrated multilevel analyses for proper QDs risk assessment. L.M. and P.R. acknowledge the French National Research Agency ANR (contracts NANOFRET, ANR-12-NANO-0007-03, NEUTRINOS, ANR-16-CE09-0015-03, and FLUO, ANR-18-CE09-0039-01). We thank Dr. Tim Senden, Dr. Christophe Lincheneau, and Dr. Karl David Wegner for QD synthesis and Fabio Agnese for TEM imaging. M.M. acknowledges financial support from the European Union′s Horizon 2020 research and innovation programme (Marie Skłodowska-Curie grant agreement No. 660228). |
| Databáze: | OpenAIRE |
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