Evaluation of the safety and efficacy of Glycyrrhiza uralensis root extracts produced using artificial hydroponic-field hybrid cultivation systems II: comparison of serum concentration of glycyrrhetinic acid serum concentration in mice
| Autor: | Kazuma Yamanaka, Atsuyuki Hishida, Takayuki Inui, Shigeki Hayashi, Noriaki Kawano, Nobuo Kawahara, Kayo Yoshimatsu, Hiroyuki Fuchino, Shinsuke Hisaka, Mitsuhiko Nose |
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| Rok vydání: | 2019 |
| Předmět: |
Metabolite
Cmax Crude drug 01 natural sciences Plant Roots chemistry.chemical_compound Mice Pharmacokinetics Hydroponics Oral administration Animals Glycyrrhiza uralensis Food science Glycyrrhizin biology 010405 organic chemistry Plant Extracts Glycyrrhiza uralensis Root biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Molecular Medicine Glycyrrhetinic Acid Female Medicine Kampo |
| Zdroj: | Journal of natural medicines. 73(3) |
| ISSN: | 1861-0293 |
| Popis: | To evaluate the safety and efficacy of Glycyrrhiza uralensis root produced using artificial hydroponic and artificial hydroponic-field hybrid cultivation systems, we investigated the pharmacokinetics of a major metabolite of glycyrrhizin (GL), glycyrrhetinic acid (GA). Hot water extracts obtained from the roots of the artificial hydroponic-field hybrid cultivated Glycyrrhiza uralensis were orally administered at a dose of 100 mg/kg as GL in mice and, compared with a commercial crude drug, Glycyrrhizae Radix. The temporal changes in serum GA concentration was found to depend on the GL concentration of the hot-water extracts. When hot-water extracts containing relatively high GL were administered, bimodal peaks appeared. In contrast, a broad single peak was detected when a hot-water extract containing relatively low GL content was administered. These tendencies in the serum GA concentration time course were observed for all samples, regardless of their derivation. Moreover, we compared the pharmacokinetic parameters and found that the Cmax and AUC0–48 values after oral administration of the extracts from Glycyrrhiza uralensis roots produced by the artificial cultivation system are within the range of variation for the commercial crude drugs. These results suggest the possibility that roots of Glycyrrhiza uralensis cultivated by the artificial hydroponic-field hybrid cultivation system can be used in addition to currently available commercial crude drugs produced from wild plant resources. |
| Databáze: | OpenAIRE |
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