Honokiol, magnolol and its monoacetyl derivative show strong anti-fungal effect on Fusarium isolates of clinical relevance
| Autor: | Ismael Malbrán, Virgilio Balmas, Davide Fabbri, Safa Oufensou, Paola Carta, Quirico Migheli, Maria Antonietta Dettori, Giovanna Delogu, Giovanna Pani, Barbara Scherm |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Honokiol Antifungal Agents Fungal Structure Pathology and Laboratory Medicine honokiol purl.org/becyt/ford/1 [https] chemistry.chemical_compound Fusarium fungal diseases purl.org/becyt/ford/3.2 [https] Medicine and Health Sciences Musculoskeletal System Mycelium Fungal Pathogens Multidisciplinary biphenili biology Traditional medicine Antimicrobials Feet Chemistry HYDROXYLATED BIPHENYLS NATURAL POLYPHENOLS Drugs Eukaryota Agriculture MITOCHONDRIAL DISFUNCTION magnolol Magnolol Fusarium oxysporum Fungicide Infectious Diseases Medical Microbiology Medicine Legs purl.org/becyt/ford/3 [https] Pathogens Anatomy Agrochemicals antifungals Research Article medicine.drug Science 030106 microbiology Microbial Sensitivity Tests Mycology Microbiology fungicides Lignans 03 medical and health sciences Microbial Control purl.org/becyt/ford/1.4 [https] medicine Humans Ciencias Agrarias Microbial Pathogens FUNGICIDE Plant Diseases Pharmacology micotossine Biphenyl Compounds Organisms Biology and Life Sciences biology.organism_classification HUMAN PATHOGENS 030104 developmental biology Fusariosis Body Limbs purl.org/becyt/ford/4.1 [https] Terbinafine mycelium fungi toes purl.org/becyt/ford/4 [https] Fluconazole |
| Zdroj: | SEDICI (UNLP) Universidad Nacional de La Plata instacron:UNLP PLoS ONE PLoS ONE, Vol 14, Iss 9, p e0221249 (2019) CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET PloS one 14 (2019): 1–16. doi:10.1371/journal.pone.0221249 info:cnr-pdr/source/autori:1 Oufensou Safa; 1Scherm Barbara; 1 Pani Giovanna; 1 Balmas Virgilio; 2 Fabbri Davide; 2 Dettori Maria Antonietta; 2 Carta Paola; 3 Malbran Ismael; 1 Migheli Quirico; 2 Delogu Giovanna/titolo:Honokiol, magnolol and its monoacetyl derivative show strong anti-fungal effect on Fusarium isolates of clinical relevance/doi:10.1371%2Fjournal.pone.0221249/rivista:PloS one/anno:2019/pagina_da:1/pagina_a:16/intervallo_pagine:1–16/volume:14 |
| Popis: | The antifungal activity of magnolol and honokiol, two naturally occurring hydroxylated biphenyls, and of their synthetic derivatives was evaluated on a collection of representative isolates of Fusarium oxysporum, F. solani and F. verticillioides of clinical and ecological concern. The tested compounds were proposed as a ‘natural’ alternative to conventional fungicides, even though a larger range of concentrations (5–400 μg/ml) was applied. The activity of magnolol and honokiol was compared with that of terbinafine (0.1–10 μg/ml), and fluconazole (1–50 μg/ml), two fungicides widely used in treating fungal infections on humans. Magnolol showed similar fungicidal activity compared to fluconazole, whereas honokiol was more effective in inhibiting mycelium growth compared to this fungicide on all tested clinical Fusarium spp. isolates. Compared to terbinafine, honokiol showed similar antifungal activity when tested on clinical F. solani isolates, whereas magnolol was less effective at all selected concentrations (5–400 μg/ml). The different position of the phenol-OH group, as well as its protection, explain different in vitro activities between magnolol, honokiol, and their derivatives. Furthermore, magnolol showed mycelium dry weight reduction at a concentration of 0.5 mM when tested on a set of agricultural isolates of Fusaria, leading to complete inhibition of some of them. Magnolol and honokiol are proposed as efficient and safe candidates for treating clinically relevant Fusaria. Facultad de Ciencias Agrarias y Forestales Centro de Investigaciones en Fitopatología |
| Databáze: | OpenAIRE |
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