Intake of marine-derived omega-3 polyunsaturated fatty acids and mortality in renal transplant recipients
| Autor: | Ilse G. Pranger, Camilo G. Sotomayor, Sabita S. Soedamah-Muthu, Stephan J. L. Bakker, Rijk O. B. Gans, Else van den Berg, Antonio W. Gomes Neto, Gerjan Navis |
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| Přispěvatelé: | Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Groningen Institute for Organ Transplantation (GIOT), Value, Affordability and Sustainability (VALUE), Lifelong Learning, Education & Assessment Research Network (LEARN), Medical and Clinical Psychology |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Cardiovascular mortality Nutrition and Disease renal transplant recipients omega-3 polyunsaturated fatty acids cardiovascular mortality all-cause mortality lcsh:TX341-641 030204 cardiovascular system & hematology Lower risk Gastroenterology Renal transplant recipients 03 medical and health sciences 0302 clinical medicine QUALITY-OF-LIFE Internal medicine Voeding en Ziekte medicine CORONARY-HEART-DISEASE Prospective cohort study FISH-OIL VLAG chemistry.chemical_classification RISK Nutrition and Dietetics business.industry Proportional hazards model Omega-3 polyunsaturated fatty acids Hazard ratio All-cause mortality Eicosapentaenoic acid Confidence interval C-REACTIVE PROTEIN Surgery 030104 developmental biology chemistry Docosahexaenoic acid OXIDATIVE DAMAGE SURVIVAL lipids (amino acids peptides and proteins) DIETARY SUPPLEMENTATION business lcsh:Nutrition. Foods and food supply Food Science Polyunsaturated fatty acid SMOKERS OMEGA-3-FATTY-ACIDS |
| Zdroj: | Nutrients, 9(4) Nutrients 9 (2017) 4 Nutrients, Vol 9, Iss 4, p 363 (2017) Nutrients; Volume 9; Issue 4; Pages: 363 Nutrients, 9(4):363. MDPI AG Nutrients, 9(4):363. Multidisciplinary Digital Publishing Institute (MDPI) |
| ISSN: | 2072-6643 |
| Popis: | The effect of marine-derived omega-3 polyunsaturated fatty acids (n-3 PUFA) on long-term outcome in renal transplant recipients (RTR) remains unclear. We investigated whether marine-derived n-3 PUFA intake is associated with all-cause and cardiovascular (CV) mortality in RTR. Intake of eicosapentaenoic acid plus docosahexaenoic acid (EPA-DHA) was assessed using a validated Food Frequency Questionnaire. Cox regression analyses were performed to evaluate the associations of EPA-DHA intake with all-cause and CV mortality. We included 627 RTR (age 53 +/- 13 years). EPA-DHA intake was 102 (42-215) mg/day. During median follow-up of 5.4 years, 130 (21%) RTR died, with 52 (8.3%) due to CV causes. EPA-DHA intake was associated with lower risk of all-cause mortality (Hazard Ratio (HR) 0.85; 95% confidence interval (95% CI) 0.75-0.97). Age (p = 0.03) and smoking status (p = 0.01) significantly modified this association, with lower risk of all-cause and CV mortality particularly in older (HR 0.75, 95% CI 0.61-0.92; HR 0.68, 95% CI 0.48-0.95) and non-smoking RTR (HR 0.80, 95% CI 0.68-0.93; HR 0.74, 95% CI 0.56-0.98). In conclusion, marine-derived n-3 PUFA intake is inversely associated with risk of all-cause and CV mortality in RTR. The strongest associations were present in subgroups of patients, which adds further evidence to the plea for EPA-DHA supplementation, particularly in elderly and non-smoking RTR. |
| Databáze: | OpenAIRE |
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