Erythrocyte membrane fatty acids in benign and progressive forms of multiple sclerosis

Autor: Geeta S.M. Ramsaransing, Jacques De Keyser, M. Rebecca Heiner Fokkema, Dorothea Heersema, Marcus W. Koch
Přispěvatelé: Gerontology
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Male
Erythrocytes
BLOOD-CELLS
WHITE MATTER
diagnosis
Membrane Lipids/*metabolism
multiple sclerosis
chemistry.chemical_compound
Erythrocytes/*metabolism
Food Habits/physiology
chemistry.chemical_classification
RISK
PLASMA
Chronic Progressive/*blood/*physiopathology
Fatty Acids
METHYL-ESTERS
Middle Aged
Multiple Sclerosis
Chronic Progressive
LINOLEIC-ACID
Erythrocyte membrane
medicine.anatomical_structure
Neurology
Disease Progression
Fatty Acids
Unsaturated
Female
Polyunsaturated fatty acid
polyunsaturated fatty acids
Adult
medicine.medical_specialty
Linoleic acid
Primary progressive
Central nervous system disease
White matter
Diagnosis
Differential
Membrane Lipids
Internal medicine
Unsaturated/metabolism
medicine
Humans
Secondary progressive
Aged
Dietary Fats/*metabolism
business.industry
ALLERGIC ENCEPHALOMYELITIS
Multiple sclerosis
Fatty Acids/*metabolism
Feeding Behavior
medicine.disease
Dietary Fats
benign multiple sclerosis
Endocrinology
chemistry
Differential
CHAIN
Neurology (clinical)
business
Zdroj: JOURNAL OF THE NEUROLOGICAL SCIENCES, 244(1-2), 123-126. ELSEVIER SCIENCE BV
ISSN: 0022-510X
Popis: BACKGROUND: There is no good explanation why a proportion of patients with multiple sclerosis (MS) have a relatively benign form of the disease. An imbalance between saturated and unsaturated fatty acids (FA) might influence the disease course of MS.AIM: To assess whether the erythrocyte membrane fatty acid composition, which is a biological marker of long term dietary FA consumption, is different between patients with benign and progressive MS.METHODS: The erythrocyte membrane FA composition was measured by gas chromatography in 23 healthy controls, 27 patients with benign MS, 32 patients with secondary progressive MS and 23 patients with primary progressive MS. None of the patients was following a special diet.RESULTS: No significant differences in levels of saturated and unsaturated FA or in omega-3- and omega-6-polyunsaturated FA were found between controls and patients with the different subtypes of MS.CONCLUSION: Our data suggest that factors other than dietary fatty acid consumption are responsible for the different disease courses of MS.
Databáze: OpenAIRE
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