Influence of conjugated linoleic acid on the porcine immune response and morbidity: a randomized controlled trial
| Autor: | Alenka Spindler-Vesel, Lidija Kompan, Drago Kompan, Tomaz Malovrh, Polona Juntes, Branka Wraber |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Necrosis Endocrinology Diabetes and Metabolism Conjugated linoleic acid Linoleic acid Sus scrofa Clinical Biochemistry Inflammation Biology Interferon-gamma chemistry.chemical_compound Endocrinology Immune system Internal medicine medicine Animals Linoleic Acids Conjugated Interferon gamma lcsh:RC620-627 Biochemistry medical integumentary system Tumor Necrosis Factor-alpha Research Biochemistry (medical) Immunity food and beverages Liver regeneration Interleukin-10 lcsh:Nutritional diseases. Deficiency diseases Liver chemistry Immunoglobulin G Models Animal Immunology biology.protein lipids (amino acids peptides and proteins) Morbidity medicine.symptom Antibody medicine.drug |
| Zdroj: | Lipids in Health and Disease, Vol 8, Iss 1, p 22 (2009) Lipids in Health and Disease |
| Popis: | Background Conjugated linoleic acid (CLA) has diverse influences on the immune response in different experimental models. In the present study we investigated the effect of CLA feeding on inflammatory and immune responses in a piglet model. We studied the duration of this effect and possible detrimental effects of CLA feeding. After 12 weeks of CLA and control supplementation and washout, animals were sacrificed and parenchymal organs were histologically examined. Results In activated peripheral mononuclear cells interferon-γ was significantly (p = 0.008) lower in the CLA group by the end of the feeding period. This effect disappeared as soon as supplementation was stopped. No differences were found in the tumour necrosis factor-α, interleukin-10 production, serum immunoglobulin-G levels and fat infiltration of the liver, except that fat storage cell infiltration was significantly (p < 0.04) higher in the CLA-fed group. The effect of time for interferon-γ, interleukin-10 and immunoglobulin-G levels was statistically significant. Conclusion At the end of the feeding period the interferon-γ response was depressed. However, the maturation of the piglet immune system in our young pig model probably outweighs the impact of CLA feeding on the immune response, even though liver fat storage cell infiltration, which plays an important role in liver regeneration, increased during CLA feeding of the piglets. |
| Databáze: | OpenAIRE |
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