Specific gel-cream as adjuvant to oral isotretinoin improved hydration and prevented TEWL increase--a double-blind, randomized, placebo-controlled study
| Autor: | Emilia Zegpi, Maria Isabel Herane, Carles Trullas, Maria José Espadas, Guillermo González Martin, Carolina De Pablo, Alfons Mirada, Héctor Fuenzalida |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Glycerol Male medicine.medical_specialty Adolescent medicine.medical_treatment Placebo-controlled study Administration Oral Dermatology Placebo law.invention Placebos Young Adult Randomized controlled trial Double-Blind Method law Skin Physiological Phenomena Acne Vulgaris medicine Humans Isotretinoin Acne Skin Inflammation Transepidermal water loss business.industry Seborrhoeic dermatitis medicine.disease Water Loss Insensible Female Dermatologic Agents business Adjuvant Gels medicine.drug |
| Zdroj: | Journal of cosmetic dermatology. 8(3) |
| ISSN: | 1473-2165 |
| Popis: | Summary Background Hydrating and emollient products are often recommended to patients under isotretinoin therapy to control the most frequent mucocutaneous side effects and to improve adherence to treatment. Aims To assess, using noninvasive biophysical tests, the clinical and instrumental effectiveness of a hydrating gel-cream compared with placebo as an adjuvant to isotretinoin for treatment of facial skin in patients with inflammatory acne. Methods Prospective, double-blind, randomized study, using MULTI SKIN MC750, on the adjuvant effect of a hydrating gel-cream for acne (active product) vs. a gel-cream without active substances (placebo). Follow-up lasted 3 months. Results Sixty-six patients were included. Thirty-four were administered the active product, and 32 placebo. Though the number of lesions fell significantly in both groups, the mean number of papules on day 30 was significantly lower in the active product group. The active product group showed a significant increase in hydration, while the placebo group showed a significant increase in transepidermal water loss (TEWL). Seborrhoea decreased significantly in both groups; there were no differences between them. Conclusions Compared with placebo, the specific gel-cream with active products as an adjuvant to oral isotretinoin improved hydration, prevented TEWL increase, and reduced inflammatory acne lesions after 30 days. |
| Databáze: | OpenAIRE |
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