The use of amiloride in potassium depletion before cardiac surgery
| Autor: | P.J. Hurley, J.D.K. North, B.N. Singh |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Adult
medicine.medical_specialty Potassium depletion Potassium medicine.medical_treatment chemistry.chemical_element Hypokalemia Furosemide medicine Humans Cardiac Surgical Procedures Diuretics Heart Failure business.industry valvular heart disease Sodium Total body potassium Middle Aged medicine.disease Amiloride Cardiac surgery chemistry Anesthesia Diuretic Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | American heart journal. 78(1) |
| ISSN: | 0002-8703 |
| Popis: | The effectiveness of the new potassium-sparing diuretic, amiloride (MK-870), in combination with furosemide has been evaluated by a balance study in 10 patients who had previously been on diuretic therapy for cardiac failure from valvular heart disease. The total exchangeable body potassium was measured by 42 K dilution principle at the beginning of the study and after an 8 day period of combined amiloride-furosemide therapy. From balance data, amiloride enhanced the natriuretic response of furosemide by 92 per cent and reduced the potassium excretion by 35 per cent. No serious side effects were encountered during the investigation. In all patients depletion of total body potassium was present at the beginning of the study. The balance data suggests that potassium balance should be maintained during long periods of treatment with furosemide together with amiloride. The therapeutic implications of the combined diuretic regime in cardiac patients in failure before open-heart surgery are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|