Exiguamine A., an Indoleamine-2,3-dioxygenase (IDO) Inhibitor Isolated from the Marine Sponge Neopetrosia exigua

Autor:	Eduardo Vottero, Rob W. M. Van Soest, Raymond J. Andersen, Harry C. Brastianos, Teatulohi Matainaho, A. Grant Mauk, Brian O. Patrick
Přispěvatelé:	Research of the Zoological Museum of Amsterdam (ZMA)
Jazyk:	angličtina
Rok vydání:	2006
Předmět:	chemistry.chemical_classification biology Stereochemistry Alkaloid Tryptophan New guinea General Medicine General Chemistry Neopetrosia exigua biology.organism_classification Biochemistry Catalysis In vitro Sponge Colloid and Surface Chemistry Enzyme chemistry Indoleamine 2 3-dioxygenase Biogenesis
Zdroj:	Journal of the American Chemical Society, 128, 16046-16047. American Chemical Society
ISSN:	1520-5126 0002-7863
Popis:	Exiguamine A (1), a hexacyclic alkaloid with an unprecedented skeleton, has been isolated from the marine sponge Neopetrosia exigua collected in Papua New Guinea. The structure of exiguamine A (1) was elucidated by a combination of spectroscopic analysis and single-crystal X-ray diffraction analysis. Exiguamine A (1) has a Ki of 210 nM for inhibition of indoleamine-2,3-dioxygenase (IDO) in vitro, making it one of the most potent IDO inhibitors known to date. A putative biogenesis for the new exiguamine skeleton starts from DOPA, tryptophan, and N,N-dimethylhydantoin.
Databáze:	OpenAIRE
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