Twenty-Year Public Health Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines in US Children
| Autor: | Raymond Farkouh, Kelly Sutton, Vincenza Snow, Stephen I. Pelton, Erica Chilson, Desmond Dillon-Murphy, Matt Wasserman, Shreeya Patel, Ruth Chapman, Rotem Lapidot |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
pneumococcal pneumonia Epidemiology literature review PCV13 Infectious and parasitic diseases RC109-216 medicine.disease_cause Pneumococcal Vaccines 0302 clinical medicine 030212 general & internal medicine bacteria Child Incidence (epidemiology) pneumococcal conjugate vaccines PCV7 vaccines pneumococcal disease Twenty-Year Public Health Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines in US Children Vaccination Infectious Diseases Streptococcus pneumoniae Pneumococcal pneumonia Medicine Vaccine-preventable diseases Public Health medicine.symptom pneumococcal vaccination Meningitis Microbiology (medical) medicine.medical_specialty 030231 tropical medicine invasive pneumococcal disease Pneumococcal Infections 03 medical and health sciences children medicine Humans Vaccines Conjugate business.industry Research Infant otitis media Pneumonia bacterial infections and mycoses medicine.disease vaccination United States PCVs IPD Otitis vaccine-preventable diseases bacterial infections incidence business |
| Zdroj: | Emerging Infectious Diseases, Vol 27, Iss 6, Pp 1627-1636 (2021) Emerging Infectious Diseases |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | Pneumococcal conjugate vaccines (PCVs) have been used in the United States since 2000. To assess the cumulative 20-year effect of PCVs on invasive pneumococcal disease (IPD) incidence among children 282,000 cases of IPD, including ≈16,000 meningitis, ≈172,000 bacteremia, and ≈55,000 bacteremic pneumonia cases. In addition, vaccination has prevented 97 million healthcare visits for otitis media, 438,914–706,345 hospitalizations for pneumonia, and 2,780 total deaths. IPD cases declined 91%, from 15,707 in 1997 to 1,382 in 2019. Average annual visits for otitis media declined 41%, from 78 visits/100 children before PCV introduction to 46 visits/100 children after PCV13 introduction. Annual pneumonia hospitalizations declined 66%–79%, from 110,000–175,000 in 1997 to 37,000 in 2019. These findings confirm the substantial benefits of PCVs for preventing IPD in children. |
| Databáze: | OpenAIRE |
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