Pattern of SARS-CoV-2 infection among dependant elderly residents living in long-term care facilities in Marseille, France, March-June 2020
| Autor: | Tran Duc Anh Ly, Didier Raoult, Michael Finaud, Stéphanie Gentile, Eric Chabrière, Sylvie Arlotto, Didier Zanini, Olivier Quenette, Gérard Daher, Hélène Mendizabal, Alain Coquet, Philippe Gautret, Alain Midejean, Patrick Augier, Berengere Labarriere, Anne Marie Morel-Roux, David Morel, Vincent Laforge, Philippe Parola, Priscilla Malfuson-Clot-Faybesse, Phuc Le-Dinh |
|---|---|
| Přispěvatelé: | Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche Biomédicale des Armées (IRBA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Aix-Marseille Université - École de médecine (AMU SMPM MED), Aix-Marseille Université - Faculté des sciences médicales et paramédicales (AMU SMPM), Aix Marseille Université (AMU)-Aix Marseille Université (AMU), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Cross-sectional study Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) medicine.medical_treatment [SDV]Life Sciences [q-bio] 030106 microbiology Asymptomatic 03 medical and health sciences 0302 clinical medicine Oxygen therapy Epidemiology medicine Pharmacology (medical) 030212 general & internal medicine business.industry General Medicine 3. Good health Long-term care Infectious Diseases Emergency medicine medicine.symptom Dependant business |
| Zdroj: | International Journal of Antimicrobial Agents International Journal of Antimicrobial Agents, 2020, 56 (6), ⟨10.1016/j.ijantimicag.2020.106219⟩ |
| DOI: | 10.1016/j.ijantimicag.2020.106219⟩ |
| Popis: | Objectives: This study aimed to report the results of SARS-CoV-2 PCR-based screening campaigns conducted on dependent elderly residents (compared with staff members) in long-term care facilities (LTCFs) in Marseille, France, and the follow-up of positive cases. Methods: Data from 1691 elderly residents and 10 0 0 members of staff were retrospectively collected through interviewing the medical teams in 24 LTCFs and using the hospitals' electronic health recording systems. Results: Elderly residents were predominantly female (64.8%) with a mean age of 83.0 years. SARS-CoV-2 detection among residents (226, 13.4%) was significantly higher than among staff members (87, 8.7%) (P < 0.001). Of the 226 infected residents, 37 (16.4%) were detected on a case-by-case basis due to their COVID-19 symptoms and 189 (83.6%) were detected through mass screening. Most (77.0%) had possible COVID-19 symptoms, including respiratory symptoms and signs (44.5%) and fever (46.5%); 23.0% were asymptomatic. A total of 116 (51.4%) patients received a course of oral hydroxychloroquine and azithromycin (HCQ-AZM) for >= 3 days; 47 (20.8%) died. Through multivariate analysis, the death rate was positively associated with being male (30.7% vs. 14.0%, OR = 3.95, P = 0.002), aged 85 years (26.1% vs. 15.6%, OR = 2.43, P = 0.041) and receiving oxygen therapy (39.0% vs. 12.9%, OR = 5.16, P < 0.001) and negatively associated with being diagnosed through mass screening (16.9% vs. 40.5%, OR = 0.20, P = 0.001) and receiving HCQ-AZM treatment >= 3 days (15.5% vs. 26.4%, OR = 0.37, P = 0.02). Conclusion: The high proportion of asymptomatic COVID-19 patients and independent factors for mortality suggest that early diagnosis and treatment of COVID-19 patients in LTCFs may be effective in saving lives. (C) 2020 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|