Re-innervation of axolotl limbs. II. Sensory nerves
| Autor: | R. F. Mark, Joan E. Schrameck, Bernadette T. Johnston |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Sensory stimulation therapy
biology Sensory Receptor Cells Central nervous system General Engineering Sensation Sensory system Hindlimb Anatomy biology.organism_classification Ambystoma Nerve Regeneration Electrophysiology medicine.anatomical_structure Axolotl Receptive field medicine General Earth and Planetary Sciences Animals Contralateral limb Cutaneous innervation Neuroscience General Environmental Science Skin |
| Zdroj: | Proceedings of the Royal Society of London. Series B, Biological sciences. 190(1098) |
| ISSN: | 0950-1193 |
| Popis: | Segmental sensory receptive fields in axolotl hindlimb skin were mapped during extracellular recording of nerve responses to light tactile stimulation. Normally, cutaneous sensory innervation patterns for a given pair of left and right hindlimbs were similar, but there was variability among animals. Individual cutaneous fibres innervated a solitary receptive field whose borders were sharply defined. When spinal nerves were crushed or cut and allowed to regrow the receptive fields re-established were similar to those on the normal contralateral limb. However, many single cutaneous fibres innervated multiple receptive fields. After cutting and interchanging the two major limb nerve branches, regenerating cutaneous nerves tended to innervate skin toward which they were directed, and receptive fields did not resemble the patterns on the control limb skin. This contrasts with the results following the same operations on the motor innervation where patterns of re-innervation do resemble the control. Regenerating cutaneous fibres apparently cannot relocate their respective original cutaneous addresses, but readily re-innervate foreign skin areas. Nerves regenerating after a crush or cut appear to follow mechanical and/or biochemical orienting clues within the nerve trunks for restoration of typical innervation patterns. It is not known how the axolotl central nervous system copes with cutaneous sensory information from mislocated nerve terminals. |
| Databáze: | OpenAIRE |
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