Endothelial IGF‐1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity

Autor: Mark T. Kearney, Jürgen E. Schneider, Michael Drozd, Nadira Yuldasheva, Amanda D. V. MacCannell, Lee D. Roberts, Jordan H. Boyle, Natallia Makava, Sean Smart, Stephen B. Wheatcroft, Richard M Cubbon, Anna Skromna, Chloe G Wilkinson, Katherine I Bridge, Claire H Ozber, David J. Beech, Irvin Teh, Piruthivi Sukumar, Natalie J Haywood, Joanna Koch-Paszkowski, Cheukyau Luk, Nicole T. Watt, Nele Warmke
Rok vydání: 2021
Předmět:
Zdroj: EMBO Rep
ISSN: 1469-3178
1469-221X
DOI: 10.15252/embr.202050767
Popis: Changes in composition of the intestinal microbiota are linked to the development of obesity and can lead to endothelial cell (EC) dysfunction. It is unknown whether EC can directly influence the microbiota. Insulin-like growth factor-1 (IGF-1) and its receptor (IGF-1R) are critical for coupling nutritional status and cellular growth; IGF-1R is expressed in multiple cell types including EC. The role of ECIGF-1R in the response to nutritional obesity is unexplored. To examine this, we use gene-modified mice with EC-specific overexpression of human IGF-1R (hIGFREO) and their wild-type littermates. After high-fat feeding, hIGFREO weigh less, have reduced adiposity and have improved glucose tolerance. hIGFREO show an altered gene expression and altered microbial diversity in the gut, including a relative increase in the beneficial genus Akkermansia. The depletion of gut microbiota with broad-spectrum antibiotics induces a loss of the favourable metabolic differences seen in hIGFREO mice. We show that IGF-1R facilitates crosstalk between the EC and the gut wall; this crosstalk protects against diet-induced obesity, as a result of an altered gut microbiota.
Databáze: OpenAIRE
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