Dissolution enhancement of curcuminviacurcumin–prebiotic inulin nanoparticles

Autor:	Mohammad M. Fares, Mutaz Sheikh Salem
Rok vydání:	2015
Předmět:	Curcumin Chemistry Pharmaceutical medicine.medical_treatment Inulin Administration Oral Pharmaceutical Science Nanoparticle Nanoclusters Diffusion chemistry.chemical_compound Drug Delivery Systems Microscopy Electron Transmission Drug Discovery medicine Humans Organic chemistry Fourier transform infrared spectroscopy Dissolution Pharmacology Chemistry Prebiotic Organic Chemistry Water Hydrogen-Ion Concentration Gastrointestinal Tract Drug Liberation Prebiotics Solubility Microscopy Electron Scanning Nanoparticles Crystallization Nuclear chemistry Conjugate
Zdroj:	Drug Development and Industrial Pharmacy. 41:1785-1792
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639045.2015.1004184
Popis:	Dissolution enhancement of curcumin via prebiotic inulin designed to orally deliver poorly water-soluble curcumin at duodenum low acidity (pH 5.5) was investigated. Different prebiotic inulin-curcumin nanoparticles were synthesized in ethanol-water binary system at different pre-adjusted pH values. Characterization via FTIR, XRD and TGA revealed the formation of curcumin-inulin conjugates, whereas surface morphology via SEM and TEM techniques implied the formation of nanoparticle beads and nanoclusters. Prebiotic inulin-curcumin nanoparticles prepared at pH 7.0 demonstrated a maximum curcumin dissolution enhancement of ≈90% with respect to 30% for curcumin alone at pH 5.5. Power law constant values were in accordance with dissolution enhancement investigations. All samples show Fickian diffusion mechanism. XRD investigations confirm that inulin maintain its crystalline structure in curcumin-inulin conjugate structure, which confirms that it can exert successfully its prebiotic role in the gastrointestinal (GI) tract. Therefore, the use of curcumin-inulin nanoparticles can perform dual-mission in the GI tract at the duodenum environment; release of 90% of curcumin followed by prebiotic activity of inulin, which will probably play a significant role in cancer therapeutics for the coming generations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110b502a57c6e83f6c029edcb5d98a88 https://doi.org/10.3109/03639045.2015.1004184 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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