Association of Single Nucleotide Polymorphisms of Adiponectin Gene with Type 2 Diabetes Mellitus, and Their Influence on Cardiovascular Risk Markers
| Autor: | Abdulrahaman A. Momin, Gouri M Bhoite, M. P. Bankar |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Very low-density lipoprotein medicine.medical_specialty Clinical Biochemistry 030209 endocrinology & metabolism Single-nucleotide polymorphism Type 2 diabetes 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Internal medicine medicine Adiponectin Cholesterol business.industry Wild type Type 2 Diabetes Mellitus nutritional and metabolic diseases medicine.disease 030104 developmental biology Endocrinology chemistry lipids (amino acids peptides and proteins) Original Article business |
| Zdroj: | Indian journal of clinical biochemistry : IJCB. 32(1) |
| ISSN: | 0970-1915 |
| Popis: | Type 2 diabetes mellitus is a genetically heterogeneous condition, characterized by insulin deficiency and/or insulin resistance. The etiology of type 2 diabetes is complex, with involvement of genetic and environmental factors. The adipose tissue protein ‘adiponectin’ is known to increase insulin sensitivity with decreased risk of type 2 diabetes mellitus. The gene for adiponectin is present on chromosome 3q27, the association of number of single nucleotide polymorphisms of adiponectin gene with type 2 diabetes and its complications have been reported. In the present study the two most common SNPs +45T/G & +276G/T, and their association with type 2 diabetes mellitus and cardiovascular markers were studied. The significant difference in genotype frequencies of +45T/G & +276G/T was found in type 2 diabetic patients and controls, with odds ratio of 1.13 & 1.26 respectively. BMI, Fasting blood glucose, fasting insulin, HOMA IR, triglyceride and VLDL cholesterol levels were increased, and HDL cholesterol level was decreased in patients carrier for +45T/G SNP than the wild type. While only decrease in the HDL cholesterol was reported in carriers for SNP +276G/T than the wild type. The logistic regression analysis revealed the positive association of SNP +45T/G with total cholesterol & LDL cholesterol. And negative association of HDL cholesterol was found with SNPs +45T/G and +276G/T. The haplotype analysis shows the alterations in means of biochemical markers in the patients having haplotype (GG) for mutant allele of SNP +45T/G and wild allele for SNP +276G/T. |
| Databáze: | OpenAIRE |
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