Stability Analysis of a Bulk-Surface Reaction Model for Membrane-Protein Clustering
| Autor: | Lucas M. Stolerman, Michael Holst, Michael Getz, Padmini Rangamani, Stefan G. Llewellyn Smith |
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| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Quantitative Biology - Subcellular Processes Chemistry Ligand Pattern formation Protein aggregation Endocytosis Vesicular transport protein 03 medical and health sciences Cytosol Mathematics - Analysis of PDEs 0302 clinical medicine Membrane FOS: Biological sciences Biophysics FOS: Mathematics Cell adhesion Subcellular Processes (q-bio.SC) 030217 neurology & neurosurgery 030304 developmental biology Analysis of PDEs (math.AP) |
| DOI: | 10.48550/arxiv.1908.05214 |
| Popis: | Protein aggregation on the plasma membrane (PM) is of critical importance to many cellular processes such as cell adhesion, endocytosis, fibrillar conformation, and vesicle transport. Lateral diffusion of protein aggregates or clusters on the surface of the PM plays an important role in governing their heterogeneous surface distribution. However, the stability behavior of the surface distribution of protein aggregates remains poorly understood. Therefore, understanding the spatial patterns that can emerge on the PM solely through protein-protein interaction, lateral diffusion, and feedback is an important step towards a complete description of the mechanisms behind protein clustering on the cell surface. In this work, we investigate the pattern formation of a reaction-diffusion model that describes the dynamics of a system of ligand-receptor complexes. The purely diffusive ligand in the cytosol can bind receptors in the PM, and the resultant ligand-receptor complexes not only diffuse laterally but can also form clusters resulting in different oligomers. Finally, the largest oligomers recruit ligands from the cytosol in a positive feedback. From a methodological viewpoint, we provide theoretical estimates for diffusion-driven instabilities of the protein aggregates based on the Turing mechanism. Our main result is a threshold phenomenon, in which a sufficiently high recruitment of ligands promotes the input of new monomeric components and consequently drives the formation of a single-patch spatially heterogeneous steady-state. Comment: 30 pages, 13 figures |
| Databáze: | OpenAIRE |
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