Adrenocorticotropic hormone and 17-hydroxyprogesterone levels during high-dose glucocorticoid supplement for the management of clitoroplasty of CYP21A2 deficiency
| Autor: | Yukihiro Hasegawa, Yasuhiro Naiki, Kenji Nanao |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Hydrocortisone Continuous infusion Endocrinology Diabetes and Metabolism Adrenocorticotropic hormone Intravenous bolus Oral dexamethasone Clitoris Dexamethasone Endocrinology Adrenocorticotropic Hormone Internal medicine medicine Humans Child Adrenal Hyperplasia Congenital business.industry 17-alpha-Hydroxyprogesterone Infant Child Preschool Clitoroplasty Vagina Hydroxyprogesterone Female Steroid 21-Hydroxylase business Glucocorticoid medicine.drug |
| Zdroj: | Endocrine journal. 51(3) |
| ISSN: | 0918-8959 |
| Popis: | ACTH and 17-hydroxyprogesterone (17OHP) levels during clitoro- and labinoplasty for CYP21A2 deficiency have not been reported. In this study, we measured these levels during surgery. Intensive glucocorticoid supplement (IGS Tx; intravenous bolus injection of daily dose (14.6 to 22.2 mg/m(2)) of hydrocortisone followed by continuous infusion of three times the daily dose for 24 hours) was done to eight patients for surgery. ACTH and 17OHP levels were generally suppressed during operation by this protocol, but mid-surgical elevations of ACTH and 17OHP levels were observed in four out of the eight. In another three patients than the eight as described, oral dexamethasone pretreatment (1 mg/m(2)) was administered for two days before surgery in addition to IGS Tx. ACTH and 17OHP levels were completely suppressed throughout operation, indicating that this kind of additional pretreatment is more effective approach. |
| Databáze: | OpenAIRE |
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