Effects of acute aerobic, resistance and combined exercises on 24-h glucose variability and skeletal muscle signalling responses in type 1 diabetics

Autor: Roberta Saltarelli, Elena Barbieri, Dean Minnock, Giacomo Valli, Vilberto Stocchi, Serena Contarelli, Giuseppe De Vito, Carel W. le Roux, Giosuè Annibalini, Mauricio Krause
Rok vydání: 2020
Předmět:
Blood Glucose
Male
Anabolism
Physiology
p38 Mitogen-Activated Protein Kinases
0302 clinical medicine
Orthopedics and Sports Medicine
Phosphorylation
General Medicine
Adaptation
Physiological
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
medicine.anatomical_structure
Type 1 diabetes
Skeletal muscle signalling
Female
Signal Transduction
Adult
medicine.medical_specialty
animal structures
Exercise modalities
03 medical and health sciences
Physiology (medical)
Internal medicine
medicine
Humans
RNA
Messenger
Muscle
Skeletal
Protein kinase B
Exercise
Myogenin
Glycemic
business.industry
Blood Glucose Self-Monitoring
fungi
Public Health
Environmental and Occupational Health
Skeletal muscle
Resistance Training
030229 sport sciences
Metabolism
Glucose variability
medicine.disease
Endocrinology
Diabetes Mellitus
Type 1
Glucose
Hypoglycaemia
business
030217 neurology & neurosurgery
Zdroj: European journal of applied physiology. 120(12)
ISSN: 1439-6327
Popis: To compare the effect of high-intensity aerobic (AER), resistance (RES), and combined (COMB: RES + AER) exercise, on interstitial glucose (IG) variability and skeletal muscle signalling pathways in type 1 diabetes (T1D). T1D participants (6 M/6F) wore a flash glucose monitoring system in four randomized sessions: one control (CONT), and one AER, RES and COMB (40 min each). Mean amplitude of glycemic excursions (MAGE), standard deviation (SD) and coefficient variation (CV) of IG were used to compare the 24 h post-exercise IG variability. Blood and muscle samples were collected to compare exercise-induced systemic and muscle signalling responses related to metabolic, growth and inflammatory adaptations. Both RES and COMB decreased the 24 h MAGE compared to CONT; additionally, COMB decreased the 24 h SD and CV. In the 6–12 h post-exercise, all exercise modalities reduced the IG CV while SD decreased only after COMB. Both AER and COMB stimulated the PGC-1α mRNA expression and promoted the splicing of IGF-1Ea variant, while Akt and p38MAPK phosphorylation increased only after RES and COMB. Additionally, COMB enhanced eEF2 activation and RES increased myogenin and MRF4 mRNA expression. Blood lactate and glycerol levels and muscle IL-6, TNF-α, and MCP-1 mRNAs increased after all exercise sessions, while serum CK and LDH level did not change. COMB is more effective in reducing IG fluctuations compared to single-mode AER or RES exercise. Moreover, COMB simultaneously activates muscle signalling pathways involved in substrate metabolism and anabolic adaptations, which can help to improve glycaemic control and maintain muscle health in T1D.
Databáze: OpenAIRE
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