Delta Opioid Receptor Expression and Function in Primary Afferent Somatosensory Neurons
| Autor: | Amaury François, Grégory Scherrer |
|---|---|
| Přispěvatelé: | Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Sensory Receptor Cells [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Pain Neurotransmission Biology Somatosensory system Article δ-opioid receptor 03 medical and health sciences Glutamatergic chemistry.chemical_compound 0302 clinical medicine Postsynaptic potential Ganglia Spinal Receptors Opioid delta Animals Humans Neurons Afferent Neurotransmitter ComputingMilieux_MISCELLANEOUS Mechanosensation Voltage-dependent calcium channel 030104 developmental biology chemistry [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Delta Opioid Receptor Pharmacology and Therapeutic Applications. Delta Opioid Receptor Pharmacology and Therapeutic Applications., pp.87-114, 2017, ⟨10.1007/164_2017_58⟩ Handb Exp Pharmacol Delta Opioid Receptor Pharmacology and Therapeutic Applications ISBN: 9783319951317 |
| Popis: | The functional diversity of primary afferent neurons of the dorsal root ganglia (DRG) generates a variety of qualitatively and quantitatively distinct somatosensory experiences, from shooting pain to pleasant touch. In recent years, the identification of dozens of genetic markers specifically expressed by subpopulations of DRG neurons has dramatically improved our understanding of this diversity and provided the tools to manipulate their activity and uncover their molecular identity and function. Opioid receptors have long been known to be expressed by discrete populations of DRG neurons, in which they regulate cell excitability and neurotransmitter release. We review recent insights into the identity of the DRG neurons that express the delta opioid receptor (DOR) and the ion channel mechanisms that DOR engages in these cells to regulate sensory input. We highlight recent findings derived from DORGFP reporter mice and from in situ hybridization and RNA sequencing studies in wild-type mice that revealed DOR presence in cutaneous mechanosensory afferents eliciting touch and implicated in tactile allodynia. Mechanistically, we describe how DOR modulates opening of voltage-gated calcium channels (VGCCs) to control glutamatergic neurotransmission between somatosensory neurons and postsynaptic neurons in the spinal cord dorsal horn. We additionally discuss other potential signaling mechanisms, including those involving potassium channels, which DOR may engage to fine tune somatosensation. We conclude by discussing how this knowledge may explain the analgesic properties of DOR agonists against mechanical pain and uncovers an unanticipated specialized function for DOR in cutaneous mechanosensation. |
| Databáze: | OpenAIRE |
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