Patients that have Undergone Hemodialysis Exhibit Lower Amyloid Deposition in the Brain: Evidence Supporting a Therapeutic Strategy for Alzheimer’s Disease by Removal of Blood Amyloid
| Autor: | Ryuji Hata, Makoto Kuroda, Shigeru Nakai, Yoshiyuki Hiki, Masao Kato, Nobuya Kitaguchi, Midori Hasegawa, Masato Abe, Kazuyoshi Sakai, Kazunori Kawaguchi, Yukio Yuzawa, Takao Senda |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Silver Staining Pathology medicine.medical_specialty Amyloid medicine.medical_treatment Plaque Amyloid Disease Statistics Nonparametric Silver stain 03 medical and health sciences 0302 clinical medicine Renal Dialysis medicine Humans Senile plaques Aged Therapeutic strategy Aged 80 and over Amyloid beta-Peptides biology business.industry General Neuroscience Brain General Medicine Psychiatry and Mental health Clinical Psychology 030104 developmental biology Amyloid deposition Case-Control Studies biology.protein Kidney Diseases Autopsy Hemodialysis Geriatrics and Gerontology Antibody business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease. 51:997-1002 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-151139 |
| Popis: | As a proof of concept that removal of blood amyloid-β (Aβ) can reduce Aβ deposition in the brains of patients with Alzheimer's disease, cortices of patients who had undergone hemodialysis (HD), which removes Aβ from the blood, were histochemically analyzed; postmortem brain sections were stained with anti-Aβ antibodies. Brains from patients who had undergone HD had significantly fewer senile plaques than those of patient who had not undergone HD. This significant difference was also confirmed by silver staining. Our findings suggest that removal of blood Aβ by hemodialysis results in lower accumulation of Aβ in the brain. |
| Databáze: | OpenAIRE |
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