Fucoidans as Potential Inhibitors of HIV-1
| Autor: | Pavel Spirin, Vladimir S. Prassolov, Boris Fehse, Stefan Horn, M M Prokofjeva, T. I. Imbs, N. M. Shevchenko, Tatyana N. Zvyagintseva |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Anti-HIV Agents
Genetic Vectors Pharmaceutical Science In Vitro Techniques Polysaccharide brown algae Phaeophyta Jurkat cells Antiviral Agents Article Cell Line human immunodeficiency virus type 1 Transduction (genetics) chemistry.chemical_compound Jurkat Cells fucoidan antiviral activity Polysaccharides Drug Discovery Murine leukemia virus Cytotoxic T cell Humans Pharmacology Toxicology and Pharmaceutics (miscellaneous) lcsh:QH301-705.5 chemistry.chemical_classification biology Dose-Response Relationship Drug Fucoidan Lentivirus biology.organism_classification Molecular biology Molecular Weight chemistry lcsh:Biology (General) Cell culture HIV-1 Moloney murine leukemia virus |
| Zdroj: | Marine Drugs Marine Drugs, Vol 11, Iss 8, Pp 3000-3014 (2013) Marine Drugs; Volume 11; Issue 8; Pages: 3000-3014 |
| ISSN: | 1660-3397 |
| Popis: | The antiviral activity of different structure fucoidans (α-l-fucans and galactofucans) was studied using two model viral systems based on a lentiviral vectors and a replication competent Moloney murine leukemia virus (Mo-MuLV). It was found that investigated fucoidans have no cytotoxic effects on Jurkat and SC-1cell at the concentration range of 0.001–100 µg/mL. Fucoidans with different efficiency suppressed transduction of Jurkat cell line by pseudo-HIV-1 particles carrying the envelope protein of HIV-1 and infection of SC-1 cells by Mo-MuLV. According to our data, all natural fucoidans can be considered as potential anti-HIV agents regardless of their carbohydrate backbone and degree of sulfating, since their activity is shown at low concentrations (0.001–0.05 µg/mL). High molecular weight fucoidans isolated from Saccharina cichorioides (1.3-α-l-fucan), and S. japonica (galactofucan) were the most effective inhibitors. |
| Databáze: | OpenAIRE |
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