Isolation and Biological Activity of Thielocins: Novel Phospholipase A2 Inhibitors Produced by Thielavia terricola RF-143
Autor: | Nobuo Uotani, Yoshimi Kawamura, Shigeru Matsutani, Kazushige Tanaka, Tadashi Yoshida, Tatsuo Tanimoto, Hiroshi Hinoo, Shozo Nakamoto, Koichi Matsumoto, Ryuji Sakazaki |
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Rok vydání: | 1995 |
Předmět: |
Magnetic Resonance Spectroscopy
Alpha (ethology) Phospholipases A Phospholipase A2 Ascomycota Drug Discovery Animals Humans Beta (finance) IC50 Chromatography High Pressure Liquid Pharmacology chemistry.chemical_classification biology Biological activity Chromatography Ion Exchange In vitro Rats Phospholipases A2 Enzyme Xanthenes chemistry Biochemistry Enzyme inhibitor Fermentation biology.protein |
Zdroj: | The Journal of Antibiotics. 48:106-112 |
ISSN: | 1881-1469 0021-8820 |
Popis: | Thielocins A2 alpha, A2 beta, A3, B1, B2 and B3 were isolated as a novel family of phospholipase A2 inhibitors from the fermentation broth of Thielavia terricola RF-143 together with thielavins and thielocins A1 alpha and A1 beta. The most potent inhibitory activity (IC50 = 0.0033 microM) against rat group II phospholipase A2 was shown by thielocin A1 beta. Against human group II phospholipase A2, thielocin B3 (IC50 = 0.076 microM) was the most potent. |
Databáze: | OpenAIRE |
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