Isolation and Biological Activity of Thielocins: Novel Phospholipase A2 Inhibitors Produced by Thielavia terricola RF-143

Autor: Nobuo Uotani, Yoshimi Kawamura, Shigeru Matsutani, Kazushige Tanaka, Tadashi Yoshida, Tatsuo Tanimoto, Hiroshi Hinoo, Shozo Nakamoto, Koichi Matsumoto, Ryuji Sakazaki
Rok vydání: 1995
Předmět:
Zdroj: The Journal of Antibiotics. 48:106-112
ISSN: 1881-1469
0021-8820
Popis: Thielocins A2 alpha, A2 beta, A3, B1, B2 and B3 were isolated as a novel family of phospholipase A2 inhibitors from the fermentation broth of Thielavia terricola RF-143 together with thielavins and thielocins A1 alpha and A1 beta. The most potent inhibitory activity (IC50 = 0.0033 microM) against rat group II phospholipase A2 was shown by thielocin A1 beta. Against human group II phospholipase A2, thielocin B3 (IC50 = 0.076 microM) was the most potent.
Databáze: OpenAIRE