Tc-99m-PEG-Liposomes for the evaluation of colitis in Crohn's disease

Autor: Gert Storm, Otto C. Boerman, Adrienne H. Brouwers, E.T.M. Dams, Ton H J Naber, Peter Laverman, Dirk J de Jong, Wim J.G. Oyen, Frans H.M. Corstens
Předmět:
Adult
Male
medicine.medical_specialty
Exacerbation
medicine.medical_treatment
Pharmaceutical Science
Colonoscopy
Metabolic aspects of gastrointestinal diseases
Enema
Scintigraphy
Gastroenterology
Polyethylene Glycols
chemistry.chemical_compound
Febris e causa ignota
Crohn Disease
Internal medicine
Humans
Medicine
Prospective Studies
Colitis
Radionuclide Imaging
Barium enema
Crohn's disease
Fever of unknown origin
Metabole aspecten van maag-
darm- en leveraandoeningen
medicine.diagnostic_test
business.industry
Development of radiopharmaceuticals for diagnosis and therapy of pathological processes
Reproducibility of Results
Technetium
Organotechnetium Compounds
Middle Aged
medicine.disease
Surgery
Ontwikkeling van radiofarmaca ten behoeve van diagnose en behandeling van ziekteprocessen
Barium sulfate
chemistry
Liposomes
Female
Barium Sulfate
Radiopharmaceuticals
business
Zdroj: Europe PubMed Central
ResearcherID
Journal of Drug Targeting, 8, pp. 225-33
Journal of Drug Targeting, 8, 225-33
ISSN: 1061-186X
Popis: In the present study, the potential role of 99mTc-PEG-liposome to determine the extent and severity of active disease of Crohn's colitis was investigated. Patients suspected of having an exacerbation of Crohn's disease underwent a 99mTc-PEG-liposome scan (740 MBq, imaging at 4 and 24 h p.i.). A barium enema or endoscopy was performed as the standard verification procedure. Disease activity indices (Clinical Disease Activity Index and Van Hees Activity Index) were calculated. In seven patients positive images of colon segments affected by Crohn's colitis were obtained using 99mTc-PEG-liposomes. Only a moderate relation between 99mTc-liposome scan grading and verification procedures was found (Spearman rank r = 0.22). In accordance with previous studies, no significant correlation was found between the clinical disease activity indices and the verification procedures. This study was prematurely terminated because of unacceptable side-effects in 3 out of 9 patients, which occured almost immediately after starting the infusion. The complaints consisted of dyspnea and facial erythema. The symptoms were self-limiting when the infusion was stopped. In conclusion, the extent of Crohn's colitis can be established non-invasively with 99mTc-PEG-liposome scintigraphy. However, in view of the encountered side-effects, the PEG-liposomal preparation may have to be modified.
Databáze: OpenAIRE
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