Physiological role for amyloid precursor protein in adult experience-dependent plasticity
| Autor: | Charles D. Gilbert, Sally A. Marik, Olav Olsen, Marc Tessier-Lavigne |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Materials science Mutant Plasticity Somatosensory system Amyloid beta-Protein Precursor Mice 03 medical and health sciences 0302 clinical medicine Cell autonomous mental disorders Amyloid precursor protein Biological neural network Animals Neuronal Plasticity Multidisciplinary integumentary system biology fungi Biological Sciences Electrophysiology 030104 developmental biology nervous system biology.protein Developmental plasticity Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Proceedings of the National Academy of Sciences. 113:7912-7917 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.1604299113 |
| Popis: | Changes in neural circuits after experience-dependent plasticity are brought about by the formation of new circuits via axonal growth and pruning. Here, using a combination of electrophysiology, adeno-associated virus-delivered fluorescent proteins, analysis of mutant mice, and two-photon microscopy, we follow long-range horizontally projecting axons in primary somatosensory cortex before and after selective whisker plucking. Whisker plucking induces axonal growth and pruning of horizontal projecting axons from neurons located in the surrounding intact whisker representations. We report that amyloid precursor protein is crucial for axonal pruning and contributes in a cell autonomous way. |
| Databáze: | OpenAIRE |
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