Predictors of locoregional recurrence in early stage buccal cancer with pathologically clear surgical margins and negative neck
| Autor: | Shakeel Uz Zaman, Shakil Aqil, Mohammad Ahsan Sulaiman |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis Lymphovascular invasion medicine.medical_treatment Young Adult 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests medicine Humans Stage (cooking) 030223 otorhinolaryngology Aged Neoplasm Staging Retrospective Studies Aged 80 and over Mouth neoplasm Chemotherapy business.industry Margins of Excision Cancer Neck dissection General Medicine Buccal administration Middle Aged Prognosis medicine.disease Surgery stomatognathic diseases Otorhinolaryngology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Mouth Neoplasms Neoplasm Recurrence Local business |
| Zdroj: | Acta Otorrinolaringológica Española. 69:226-230 |
| ISSN: | 0001-6519 |
| Popis: | Objective To identify the significant predictors of locoregional recurrence in early stage squamous cell carcinoma (SCC) of buccal mucosa with pathologically clear surgical margins and negative neck. Method Seventy-three patients who underwent per oral wide excision and supraomohyoid neck dissection for early stage buccal SCC with clear surgical margins (>5 mm margins each) and negative neck (N0) were included. None of the patients received postoperative radiotherapy or chemotherapy. Univariate and multivariate analyses were used to identify independent predictors of locoregional recurrence. Results Recurrence was observed in 22 of 73 (30%) cases. Twelve had local, seven had regional and three developed locoregional recurrences. Both univariate and multivariate analyses demonstrated that lymphovascular invasion (LVI) and non-T4 muscular invasion (non-T4MI) were independent predictors affecting locoregional control. Conclusion Lymphovascular invasion (LVI) and non-T4 muscular invasion (non-T4MI) significantly increased the locoregional recurrence rate in early stage buccal SCC with clear surgical margins and negative nodal status. Adjuvant treatment with either radiation or chemoradiation should be considered when one or both of these factors present. |
| Databáze: | OpenAIRE |
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