Aspirin Resistance in Hypertensive Patients
| Autor: | Beste Ozben, Oguz Caymaz, Azra Meryem Tanrikulu, Tomris Ozben |
|---|---|
| Přispěvatelé: | Ozben, Beste, Tanrikulu, Azra M., Ozben, Tomris, Caymaz, Oguz |
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Drug Resistance BLOOD-PRESSURE Drug resistance Gastroenterology law.invention chemistry.chemical_compound Randomized controlled trial law Internal medicine PLATELET RESPONSE NONRESPONSIVENESS Internal Medicine medicine Humans Platelet ASPIRIN RESISTANCE Aged IIIA POLYMORPHISM Aspirin Creatinine business.industry LOW-DOSE ASPIRIN DIABETES-MELLITUS IN-VITRO Odds ratio Middle Aged Original Papers PREVENTION PREVALENCE Surgery Treatment Outcome Blood pressure chemistry Hypertension RISK-FACTORS Female Cardiology and Cardiovascular Medicine business Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | J Clin Hypertens (Greenwich) |
| ISSN: | 1524-6175 |
| DOI: | 10.1111/j.1751-7176.2010.00307.x |
| Popis: | Aspirin resistance is associated with poor clinical prognosis. The authors investigated aspirin resistance in 200 hypertensive patients (111 men, age: 68.3 +/- 11.4 years) by the Ultegra Rapid Platelet Function Assay-ASA (Accumetrics Inc., San Diego, CA). Aspirin resistance was defined as an aspirin reaction unit >= 550. Aspirin resistance was detected in 42 patients. Aspirin resistance was present in 25.6% of the patients with poor blood pressure control, while in 17.8% of the patients with controlled blood pressure (P=.182). Female gender and creatinine levels were significantly higher (P=.028 and P=.030, respectively), while platelet count was significantly lower (P=.007) in aspirin-resistant patients. Multivariate analysis revealed that female gender (odds ratio [OR], 2.445; P=.045), creatinine levels (OR, 1.297; P=.015) and platelet count (OR, 0.993; P=.005) were independent predictors of aspirin resistance. The frequency of aspirin resistance is not low in hypertensive patients. Female hypertensive patients, especially, with higher creatinine levels and lower platelet count are at higher risk for aspirin resistance. J Clin Hypertens (Greenwich). 2010; 12: 714-720. (C) 2010 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|