Antiplatelet and anticoagulation regimen in patients with mechanical valve undergoing PCI – State-of-the-art review
| Autor: | Ron Waksman, Toby Rogers, Micaela Iantorno, Lowell F. Satler, Itsik Ben-Dor, Kyle Buchanan, Deepakraj Gajanana, Augusto D. Pichard, Petros Okubagzi, Rebecca Torguson |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Hemorrhage 030204 cardiovascular system & hematology Mechanical valve 03 medical and health sciences Percutaneous Coronary Intervention 0302 clinical medicine P2Y12 medicine Humans cardiovascular diseases 030212 general & internal medicine Intensive care medicine Aspirin business.industry Anticoagulants Percutaneous coronary intervention Regimen Heart Valve Prosthesis Concomitant Cohort Conventional PCI Purinergic P2Y Receptor Antagonists Drug Therapy Combination Risk Adjustment Cardiology and Cardiovascular Medicine business Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | International Journal of Cardiology. 264:39-44 |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/j.ijcard.2018.03.107 |
| Popis: | A common clinical dilemma regarding treatment of patients with a mechanical valve is the need for concomitant antiplatelet therapy for a variety of reasons, referred to as triple therapy. Triple therapy is when a patient is prescribed aspirin, a P2Y12 antagonist, and an oral anticoagulant. Based on the totality of the available evidence, best practice in 2017 for patients with mechanical valves undergoing percutaneous coronary intervention (PCI) is unclear. Furthermore, the optimal duration of dual antiplatelet therapy after PCI is evolving. With better valve designs that are less thrombogenic, the thromboembolic risks can be reduced at a lower international normalized ratio target, thus decreasing the bleeding risk. This review will offer an in-depth survey of current guidelines, current evidence, suggested approach for PCI in this cohort, and future studies regarding mechanical valve patients undergoing PCI. |
| Databáze: | OpenAIRE |
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