Essential role of Nr2f nuclear receptors in patterning the vertebrate upper jaw
| Autor: | Lisa Del Rio, Pauline Rataud, Kasra Behizad, Lindsey Barske, Samuel G. Cox, J. Gage Crump |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Mutant Biology General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences stomatognathic system biology.animal Gene expression medicine Maxilla Animals Progenitor cell Molecular Biology Zebrafish Body Patterning Endothelin-1 Cartilage Vertebrate Gene Expression Regulation Developmental Cell Biology Zebrafish Proteins Chondrogenesis biology.organism_classification Cell biology DNA-Binding Proteins stomatognathic diseases 030104 developmental biology medicine.anatomical_structure Nuclear receptor Jaw Mutation Odontogenesis Developmental Biology Signal Transduction Transcription Factors |
| Popis: | Summary The jaw is central to the extensive variety of feeding and predatory behaviors across vertebrates. The bones of the lower but not upper jaw form around an early-developing cartilage template. Whereas Endothelin1 patterns the lower jaw, the factors that specify upper-jaw morphology remain elusive. Here, we identify Nuclear Receptor 2f genes (Nr2fs) as enriched in and required for upper-jaw formation in zebrafish. Combinatorial loss of Nr2fs transforms maxillary components of the upper jaw into lower-jaw-like structures. Conversely, nr2f5 misexpression disrupts lower-jaw development. Genome-wide analyses reveal that Nr2fs repress mandibular gene expression and early chondrogenesis in maxillary precursors. Rescue of lower-jaw defects in endothelin1 mutants by reducing Nr2f dosage further demonstrates that Nr2f expression must be suppressed for normal lower-jaw development. We propose that Nr2fs shape the upper jaw by protecting maxillary progenitors from early chondrogenesis, thus preserving cells for later osteogenesis. |
| Databáze: | OpenAIRE |
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