Murine arylsulfatase C: evidence for two isozymes
| Autor: | B. M. Keinanen, K. Nelson, W. L. Daniel |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Dehydroepiandrosterone Spleen Mice Inbred Strains Biology Isozyme Cellular and Molecular Neuroscience Mice Species Specificity medicine Steroid sulfatase Animals Tissue Distribution Molecular Biology Gene Arylsulfatases Pharmacology Kidney Sex Characteristics Sulfatase Cell Biology Isoenzymes medicine.anatomical_structure Biochemistry Genes biology.protein Molecular Medicine Female Steryl-Sulfatase Sulfatases Arylsulfatase |
| Zdroj: | Experientia. 39(7) |
| ISSN: | 0014-4754 |
| Popis: | SWR/J mice possess high arylsulfatase C, estrone sulfatase, and dehydroepiandrosterone sulfatase activities in liver, spleen, and kidney compared to A/J mice. This interstrain activity variation appears to be determined by at least 1 autosomal gene. Murine arylsulfatase C activity occurs in both hydrophobic and hydrophilic forms which differ with respect to certain biochemical properties and exhibit different subcellular distributions. The hydrophilic isozyme is a major component in kidney and brain extracts and a minor isozyme in liver and spleen extracts. The hydrophobic arylsulfatase C isozyme appears to be identical to steroid sulfatase. The hydrophilic arylsulfatase C isozyme does not possess steroid sulfatase activity; however, hydrophilic and hydrophobic arylsulfatase C share certain properties, suggesting that they may be structurally related. The autosomal gene(s) affects both arylsulfatase isozymes. |
| Databáze: | OpenAIRE |
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