Role of contrast-enhanced ultrasound in the blinded assessment of focal liver lesions in comparison with MDCT and CEMRI: Results from a multicentre clinical trial

Autor: Jean-Pierre Tasu, M.F. Bellin, J. Drouillard, Christophe Aubé, D. Marion, Emmanuel Rusch, Bruno Giraudeau, P. Manzoni, Herve Trillaud, A. Le Gouge, Jean Michel Correas, L. Chami, V. Ladam Marcus, A. Rode, B. Gallix, A. Fayault, François Tranquart, M. Cuilleron, V. Vilgrain, O. Lucidarme, M. Claudon
Rok vydání: 2008
Předmět:
Zdroj: European Journal of Cancer Supplements. 6(11):9-15
ISSN: 1359-6349
DOI: 10.1016/j.ejcsup.2008.06.003
Popis: The main aim of this multicentre prospective study was to determine the clinical value of SonoVue® administration for the characterisation of focal liver lesions incidentally detected in oncological or cirrhotic patients. Eight hundred and seventy four consecutive patients with 1034 nodules (diameter between 5 and 100 mm) not fully characterised by conventional US or previous single-phase CT-scan were imaged using real-time contrast-enhanced scanning after intravenous injection of 2.4 ml of SonoVue® Blinded off-site assessment was conducted to evaluate the diagnostic performance of contrast-enhanced ultrasound (CEUS) in comparison with gold standard, i.e. triphasic CT-scan or contrast-enhanced MRI or histology. In the differentiation between benign and malignant lesions, CEUS yielded a sensitivity of 79.4% and a specificity of 88.1%. In the subgroup of patients with cirrhosis, the kappa value for off-site diagnosis between CEUS and reference modality was slightly lower compared to the non-cirrhotic group: 0.42 and 0.66 (p = 0.0002), respectively. The concordance rate and kappa value of CEUS for benign to malignant differentiation between on-site and blinded review were 90.2% and 0.80%, respectively, compared to 83.4% and 0.66%, respectively, for the reference imaging technique. These results indicate that CEUS using SonoVue® is a competitive and effective diagnostic tool for the characterisation of focal liver lesions compared to other modalities such as CT and MR imaging.
Databáze: OpenAIRE
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