Prevalence and Risk Factors Associated to Chronic Kidney Disease in HIV-Infected Patients on HAART and Undetectable Viral Load in Brazil
Autor: | Andréia Magalhães de Menezes, Lucia Real, Jorge Torelly, Mônica Bay, Eduardo Sprinz, Julia Poeta |
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Jazyk: | angličtina |
Rok vydání: | 2011 |
Předmět: |
Male
lcsh:Medicine HIV Infections Disease urologic and male genital diseases Cardiovascular Kidney Function Tests Risk Factors Antiretroviral Therapy Highly Active Chronic Kidney Disease Prevalence Outpatient clinic Medicine lcsh:Science education.field_of_study Multidisciplinary Obstetrics and Gynecology HIV diagnosis and management Middle Aged Viral Load Nephrology Cohort Hypertension Infectious diseases HIV clinical manifestations Female Viral load Brazil Research Article Adult medicine.medical_specialty Adolescent Urology Population Renal function Viral diseases Young Adult Internal medicine Humans education Aged Demography Pregnancy business.industry Genitourinary Infections lcsh:R HIV medicine.disease Diet Immunology Multivariate Analysis Kidney Failure Chronic lcsh:Q business Kidney disease |
Zdroj: | PLoS ONE PLoS ONE, Vol 6, Iss 10, p e26042 (2011) |
ISSN: | 1932-6203 |
Popis: | BACKGROUND: To determine the prevalence and associated factors with chronic kidney disease (CKD) in a cohort of HIV-positive individuals with undetectable viral load on HAART. METHODS: From March, 2009 to September 2009, 213 individuals between 18-70 years, period on HAART ≥12 months, viral load < 50 copies/mm(3), and CD4 ≥ 200 cells/mm(3), were consecutively enrolled at the outpatient clinic of Hospital de Clínicas, Porto Alegre, Brazil. Exclusion criteria were obesity, malnourishment, amputee, paraplegic, previous history of renal disease, pregnancy and hepatic insufficiency. Renal function was determined by estimated glomerular filtration rate (eGFR) assessed by the modification of diet in renal disease. CKD was defined as an eGFR less or equal than 60 ml/min/1.73 m(2), for a period of at least 3 months. Poisson regression was used to determine factors associated with CKD. RESULTS: CKD was diagnosed in 8.4% of the population, and after adjustment, the risk factors were hypertension (RR = 3.88, 95%CI, 1.84-8.16), time on HAART (RR = 1.15, 95%CI,1.03-1.27) and tenofovir exposure (RR = 2.25, 95%CI, 1.04-4.95). Higher weight (RR = 0.88 95%CI, 0.82-0.96) was associated to normal function. CONCLUSIONS: CKD was a common finding in this cohort of patients and was related to hypertension, time on HAART and tenofovir exposure. We suggest a more frequent monitoring of renal function, especially for those with risk factors to early identify renal impairment. |
Databáze: | OpenAIRE |
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