Prevalence and Risk Factors Associated to Chronic Kidney Disease in HIV-Infected Patients on HAART and Undetectable Viral Load in Brazil

Autor: Andréia Magalhães de Menezes, Lucia Real, Jorge Torelly, Mônica Bay, Eduardo Sprinz, Julia Poeta
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Male
lcsh:Medicine
HIV Infections
Disease
urologic and male genital diseases
Cardiovascular
Kidney Function Tests
Risk Factors
Antiretroviral Therapy
Highly Active
Chronic Kidney Disease
Prevalence
Outpatient clinic
Medicine
lcsh:Science
education.field_of_study
Multidisciplinary
Obstetrics and Gynecology
HIV diagnosis and management
Middle Aged
Viral Load
Nephrology
Cohort
Hypertension
Infectious diseases
HIV clinical manifestations
Female
Viral load
Brazil
Research Article
Adult
medicine.medical_specialty
Adolescent
Urology
Population
Renal function
Viral diseases
Young Adult
Internal medicine
Humans
education
Aged
Demography
Pregnancy
business.industry
Genitourinary Infections
lcsh:R
HIV
medicine.disease
Diet
Immunology
Multivariate Analysis
Kidney Failure
Chronic
lcsh:Q
business
Kidney disease
Zdroj: PLoS ONE
PLoS ONE, Vol 6, Iss 10, p e26042 (2011)
ISSN: 1932-6203
Popis: BACKGROUND: To determine the prevalence and associated factors with chronic kidney disease (CKD) in a cohort of HIV-positive individuals with undetectable viral load on HAART. METHODS: From March, 2009 to September 2009, 213 individuals between 18-70 years, period on HAART ≥12 months, viral load < 50 copies/mm(3), and CD4 ≥ 200 cells/mm(3), were consecutively enrolled at the outpatient clinic of Hospital de Clínicas, Porto Alegre, Brazil. Exclusion criteria were obesity, malnourishment, amputee, paraplegic, previous history of renal disease, pregnancy and hepatic insufficiency. Renal function was determined by estimated glomerular filtration rate (eGFR) assessed by the modification of diet in renal disease. CKD was defined as an eGFR less or equal than 60 ml/min/1.73 m(2), for a period of at least 3 months. Poisson regression was used to determine factors associated with CKD. RESULTS: CKD was diagnosed in 8.4% of the population, and after adjustment, the risk factors were hypertension (RR = 3.88, 95%CI, 1.84-8.16), time on HAART (RR = 1.15, 95%CI,1.03-1.27) and tenofovir exposure (RR = 2.25, 95%CI, 1.04-4.95). Higher weight (RR = 0.88 95%CI, 0.82-0.96) was associated to normal function. CONCLUSIONS: CKD was a common finding in this cohort of patients and was related to hypertension, time on HAART and tenofovir exposure. We suggest a more frequent monitoring of renal function, especially for those with risk factors to early identify renal impairment.
Databáze: OpenAIRE
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