MR imaging of diffuse adenomyosis changes after GnRH analog therapy
| Autor: | Susan M. Ascher, James A. Simon, Lori L. Arnold, Izumi Imaoka, Hong Li, Felicia Cuomo, Kazuro Sugimura, Kentaro Takahashi |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
medicine.medical_specialty Treatment outcome Uterus Endometriosis Gonadotropin-Releasing Hormone Nuclear magnetic resonance Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Adenomyosis Prospective Studies medicine.diagnostic_test business.industry Myometrium Magnetic resonance imaging GnRH Analog Middle Aged medicine.disease Mr imaging Magnetic Resonance Imaging medicine.anatomical_structure Endocrinology Treatment Outcome Female Signal intensity business |
| Zdroj: | Journal of magnetic resonance imaging : JMRI. 15(3) |
| ISSN: | 1053-1807 |
| Popis: | Purpose To evaluate uterine changes on MRI before and after GnRH analog (GnRHa) treatment in diffuse adenomyosis. Materials and Methods Thirty-one patients with MRI features suggestive of diffuse adenomyosis received GnRHa for 6 months. Diffuse adenomyosis was sub-classified as: symmetric (symmetric/ entire widening of the junctional zone [JZ]) and asymmetric (asymmetric/ partial widening of JZ). Pre- and post-high signal intensity (SI) foci and JZ width, and post-demarcated change (interface of adenomyosis with the myometrium became more discrete with a concomitant decrease in JZ width) were analyzed. Results Before therapy, 15 of 18 asymmetric contained high SI foci compared to none of symmetric. After therapy, JZ width decreased (P < 0.0001). Eight asymmetric and none of symmetric showed demarcated change with resolved high SI foci. Conclusion Our results suggest the use of GnRHa is associated with a decrease of JZ width in adenomyosis. Asymmetric adenomyosis with high SI foci appears to be the most sensitive to hormonal therapy. J. Magn. Reson. Imaging 2002;15:285–290. © 2002 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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